The Role of Centrosome Misorientation and miR-1270 in Impaired Endothelial Cell Migration in Preeclampsia

Abstract

Preeclampsia is a serious pregnancy-related disorder that poses significant health risks to the mother and offspring. A key aspect of preeclampsia is impaired endothelial cell migration, which is essential for the repair and integrity of the vasculature. Preeclamptic endothelial progenitor cells (EPC) exhibit defects in migration, although the precise molecular mechanisms underlying these defects remain unclear. Cellular spatial organization, such as centrosome orientation, regulates the migration process by influencing cell polarity and movement. Epigenetic changes in preeclampsia may disrupt these processes and thus impair endothelial function. We recently described the role of microRNA (miR)-1270 in preeclamptic EPC, linking its dysregulated expression to impaired EPC motility. Here, we demonstrate that endothelial cell migration defects in preeclampsia, along with reduced miR-1270 levels, are accompanied by changes in centrosome orientation. This study provides novel insights into the molecular consequences of preeclampsia and its detrimental effects on endothelial dynamics.