Prevalence of vasculitis, systemic lupus erythematosus, rheumatoid arthritis, systemic sclerosis, idiopathic inflammatory myopathies and spondyloarthritis in Australia: a systematic review and meta-analysis.
L Roper, E Cameron, T Yu, N Li, M Parker, N Nassar, M Nikpour
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引用次数: 0
Abstract
Background: Systemic autoimmune rheumatic diseases (SARDs), including vasculitis, systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), systemic sclerosis (SSc), idiopathic inflammatory myopathies (IIM), spondyloarthritis (SpA), Sjogrens disease (SjD) and mixed connective tissue disease (MCTD), are rare but associated with substantial morbidity and healthcare burden. Their clinical heterogeneity and diagnostic complexity pose challenges for epidemiological study.
Objective: To summarise Australian data on the incidence or prevalence of the SARDs listed above.
Methods: Scientific databases were searched in July 2024. Studies reporting SARD incidence or prevalence in the general Australian population were included. Where three or more studies of the same disease existed within a comparable population, which were not at high risk of bias (Hoy Tool), a random effects model was fitted.
Results: From 1357 publications, 58 were included, on: vasculitis (16), SLE (14), RA (10), SSc (nine), IIM (six) and SpA (three), with none on SjD or MCTD identified. Meta-analysis was possible in ANCA-associated vasculitis (AAV) (incidence 10.80 per million person-years), SLE (prevalence 57.86 per 100 000), lupus nephritis (prevalence 11.20 per 100 000, incidence 1.02 per 100 000 person-years), SSc (prevalence 25.58 per 100 000), IIM (incidence 9.96 per million person-years) and inclusion body myositis (prevalence 27.73 per million). Data were limited for paediatric populations and specific at-risk groups (e.g. Australians of Asian heritage).
Conclusion: Australia may have above-average prevalence of SLE and SSc and geographic variation in SSc and AAV. Key research gaps include: (1) sparse data for non-AAV vasculitis, RA, SpA, SjD, MCTD and children; (2) limited validated algorithms to identify SARDs in administrative health data; and (3) a need for large-scale spatial studies to detect disease clusters.
期刊介绍：
The Internal Medicine Journal is the official journal of the Adult Medicine Division of The Royal Australasian College of Physicians (RACP). Its purpose is to publish high-quality internationally competitive peer-reviewed original medical research, both laboratory and clinical, relating to the study and research of human disease. Papers will be considered from all areas of medical practice and science. The Journal also has a major role in continuing medical education and publishes review articles relevant to physician education.
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