Baseline and longitudinal changes of body roundness index and incident type 2 diabetes: evidence from the UK Biobank cohort.

IF 4.1 2区 医学 Q2 ENDOCRINOLOGY & METABOLISM
Xuanli Zhao, Fangyuan Jing, Yanan Ren, Jing Zhu, Xinzhe Jing, Meiqun Lv, Ke Huang, Jing Guo, Jiayu Li, Xiaohui Sun, Yingying Mao, Ding Ye
{"title":"Baseline and longitudinal changes of body roundness index and incident type 2 diabetes: evidence from the UK Biobank cohort.","authors":"Xuanli Zhao, Fangyuan Jing, Yanan Ren, Jing Zhu, Xinzhe Jing, Meiqun Lv, Ke Huang, Jing Guo, Jiayu Li, Xiaohui Sun, Yingying Mao, Ding Ye","doi":"10.1136/bmjdrc-2025-005339","DOIUrl":null,"url":null,"abstract":"<p><strong>Introduction: </strong>Type 2 diabetes (T2D) is closely associated with excess adiposity, particularly visceral fat. The body roundness index (BRI), calculated from height and waist circumference, provides a refined estimate of visceral adiposity. This study aimed to investigate the associations of baseline BRI and longitudinal changes in BRI with the risk of incident T2D.</p><p><strong>Research design and methods: </strong>We used UK Biobank data, a cohort involving adults aged 37-73 years. Both baseline and last follow-up BRI values were classified according to the tertiles of baseline BRI, and long-term BRI changes were categorized by baseline and follow-up grades. The annual average rate of change (AARC) of BRI was also calculated. Cox regression models were employed to evaluate HRs and 95% CIs, while restricted cubic splines explored non-linear relationships.</p><p><strong>Results: </strong>Among 485 509 participants, 32 956 developed T2D during the follow-up period. Elevated baseline BRI was correlated with a greater risk of T2D, with adjusted HRs of 2.39 (95% CI: 2.28 to 2.51) and 6.23 (95% CI: 5.96 to 6.50) for the second and third tertiles of BRI, respectively. In the longitudinal analysis of 65 684 participants (1153 T2D cases), low baseline BRI with grade increase was linked to higher risk of T2D (HR: 1.49, 95% CI: 1.05 to 2.13). Among participants with middle baseline BRI, grade decrease and increase showed HRs of 0.65 (95% CI: 0.45 to 0.93) and 1.66 (95% CI: 1.32 to 2.10) versus stable middle. Grade decrease with high baseline BRI was associated with lower T2D risk (HR: 0.50, 95% CI: 0.40 to 0.62) compared with stable high. Non-linear associations between AARC of BRI and T2D risk were identified (p <0.05).</p><p><strong>Conclusions: </strong>This study shows that both baseline BRI and long-term BRI changes are linked to T2D risk, emphasizing the significance of monitoring BRI trends for T2D prevention and control.</p>","PeriodicalId":9151,"journal":{"name":"BMJ Open Diabetes Research & Care","volume":"13 5","pages":""},"PeriodicalIF":4.1000,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12439138/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"BMJ Open Diabetes Research & Care","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1136/bmjdrc-2025-005339","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}
引用次数: 0

Abstract

Introduction: Type 2 diabetes (T2D) is closely associated with excess adiposity, particularly visceral fat. The body roundness index (BRI), calculated from height and waist circumference, provides a refined estimate of visceral adiposity. This study aimed to investigate the associations of baseline BRI and longitudinal changes in BRI with the risk of incident T2D.

Research design and methods: We used UK Biobank data, a cohort involving adults aged 37-73 years. Both baseline and last follow-up BRI values were classified according to the tertiles of baseline BRI, and long-term BRI changes were categorized by baseline and follow-up grades. The annual average rate of change (AARC) of BRI was also calculated. Cox regression models were employed to evaluate HRs and 95% CIs, while restricted cubic splines explored non-linear relationships.

Results: Among 485 509 participants, 32 956 developed T2D during the follow-up period. Elevated baseline BRI was correlated with a greater risk of T2D, with adjusted HRs of 2.39 (95% CI: 2.28 to 2.51) and 6.23 (95% CI: 5.96 to 6.50) for the second and third tertiles of BRI, respectively. In the longitudinal analysis of 65 684 participants (1153 T2D cases), low baseline BRI with grade increase was linked to higher risk of T2D (HR: 1.49, 95% CI: 1.05 to 2.13). Among participants with middle baseline BRI, grade decrease and increase showed HRs of 0.65 (95% CI: 0.45 to 0.93) and 1.66 (95% CI: 1.32 to 2.10) versus stable middle. Grade decrease with high baseline BRI was associated with lower T2D risk (HR: 0.50, 95% CI: 0.40 to 0.62) compared with stable high. Non-linear associations between AARC of BRI and T2D risk were identified (p <0.05).

Conclusions: This study shows that both baseline BRI and long-term BRI changes are linked to T2D risk, emphasizing the significance of monitoring BRI trends for T2D prevention and control.

Abstract Image

Abstract Image

Abstract Image

身体圆度指数的基线和纵向变化与2型糖尿病的发生:来自英国生物银行队列的证据
2型糖尿病(T2D)与过度肥胖,尤其是内脏脂肪密切相关。身体圆度指数(BRI),由身高和腰围计算,提供了内脏肥胖的精确估计。本研究旨在探讨基线BRI和BRI纵向变化与T2D发生风险的关系。研究设计和方法:我们使用了英国生物银行的数据,一个涉及37-73岁成年人的队列。基线和最后一次随访BRI值根据基线BRI的位数进行分类,长期BRI变化根据基线和随访等级进行分类。计算了BRI的年平均变化率(AARC)。采用Cox回归模型评估hr和95% ci,而限制三次样条则探讨非线性关系。结果:在485 509名参与者中,32 956人在随访期间发生了T2D。升高的基线BRI与更高的T2D风险相关,BRI的第二和第三分位数调整后的hr分别为2.39 (95% CI: 2.28至2.51)和6.23 (95% CI: 5.96至6.50)。在65 684名参与者(1153例T2D病例)的纵向分析中,低基线BRI与分级增加与T2D的高风险相关(HR: 1.49, 95% CI: 1.05至2.13)。在中度基线BRI的参与者中,等级下降和增加的hr分别为0.65 (95% CI: 0.45至0.93)和1.66 (95% CI: 1.32至2.10)。与稳定的高基线相比,高基线BRI的分级降低与较低的T2D风险相关(HR: 0.50, 95% CI: 0.40至0.62)。结论:该研究表明,基线BRI和长期BRI变化都与T2D风险有关,强调了监测BRI趋势对T2D预防和控制的重要性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
BMJ Open Diabetes Research & Care
BMJ Open Diabetes Research & Care Medicine-Endocrinology, Diabetes and Metabolism
CiteScore
9.30
自引率
2.40%
发文量
123
审稿时长
18 weeks
期刊介绍: BMJ Open Diabetes Research & Care is an open access journal committed to publishing high-quality, basic and clinical research articles regarding type 1 and type 2 diabetes, and associated complications. Only original content will be accepted, and submissions are subject to rigorous peer review to ensure the publication of high-quality — and evidence-based — original research articles.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信