Cell-Penetrating Peptoids: A Dual Functional Strategy for Upcoming Neuroregeneration Application

IF 3.9 3区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

ACS Chemical Neuroscience Pub Date : 2025-09-15 DOI:10.1021/acschemneuro.5c00693

Pratikshya Paudel, , , Rupali Kaur, , and , Prabir Kumar Gharai*,

引用次数: 0

Abstract

Effective therapies for neurological conditions are a significant challenge since limited capacity of neurons for regeneration affects neuronal recovery. Despite their ineffective in vivo direct development into neurons, human mesenchymal stem cells (hMSCs) exhibit therapeutic promise through immunological regulation, neuroprotection, and improvement of endogenous repair. A promising strategy is to convert hMSCs into functional neurons using peptoids that also possess cell-penetrating abilities. Therefore, developing cell-penetrating peptoids that combine effective cellular uptake with neural differentiation induction could significantly progress neuroscience research and neuroregenerative treatments.

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细胞穿透肽：即将到来的神经再生应用的双重功能策略。

神经系统疾病的有效治疗是一个重大挑战，因为有限的神经元再生能力影响了神经元的恢复。尽管人间充质干细胞（hMSCs）在体内不能直接发育成神经元，但它通过免疫调节、神经保护和改善内源性修复表现出治疗前景。一种很有前景的策略是使用具有细胞穿透能力的肽类物质将hMSCs转化为功能性神经元。因此，开发细胞穿透类肽，将有效的细胞摄取与神经分化诱导结合起来，可以显著推进神经科学研究和神经再生治疗。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ACS Chemical Neuroscience BIOCHEMISTRY & MOLECULAR BIOLOGY-CHEMISTRY, MEDICINAL

CiteScore

9.20

自引率

4.00%

发文量

323

审稿时长

1 months

期刊介绍： ACS Chemical Neuroscience publishes high-quality research articles and reviews that showcase chemical, quantitative biological, biophysical and bioengineering approaches to the understanding of the nervous system and to the development of new treatments for neurological disorders. Research in the journal focuses on aspects of chemical neurobiology and bio-neurochemistry such as the following: Neurotransmitters and receptors Neuropharmaceuticals and therapeutics Neural development—Plasticity, and degeneration Chemical, physical, and computational methods in neuroscience Neuronal diseases—basis, detection, and treatment Mechanism of aging, learning, memory and behavior Pain and sensory processing Neurotoxins Neuroscience-inspired bioengineering Development of methods in chemical neurobiology Neuroimaging agents and technologies Animal models for central nervous system diseases Behavioral research