The Associations Between Chronic Active Lesions and White Matter Disease: A 7 Tesla Imaging Study.

IF 3.9 2区医学 Q1 CLINICAL NEUROLOGY

Annals of Clinical and Translational Neurology Pub Date : 2025-09-16 DOI:10.1002/acn3.70101

Ellie McCluey, Ahmad A Toubasi, Jiacheng Wang, Habeeb F Kazimuddin, Taegan Vinarsky, Caroline Gheen, Carynn Koch, Zachery Rohm, Bryan Hernandez, Margareta A Clarke, Rachael Cheek, Rozita Khalili, Chaoyang Jin, Victoria Lim, John Kramer, Junzhong Xu, Ipek Oguz, Francesca Bagnato

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引用次数: 0

Abstract

Background: The relationship between paramagnetic rim lesions (PRLs) and surrounding normally appearing white matter (NAWM) disease, potentially contributory to the associations seen between PRLs and clinical impairment, is underexplored.

Objectives: To assess whether PRLs correlate with a greater degree of NAWM injury in early MS.

Methods: PRLs were identified on susceptibility weighted imaging (SWI) of 68 newly diagnosed patients. Each PRL was paired with an anatomically matched contralateral non-PRL (nPRL) from the same participant. Quantitative magnetization transfer imaging derived macromolecular-to-free pool-size ratio (PSR) and relaxation rate of the free water pool (R_1f) values were extracted and compared between PRLs and nPRLs, NAWM surrounding PRLs and nPRLs, and whole brain WM lesions and NAWM of PRL+ and PRL- people with MS (pwMS).

Results: PSR and R_1f (p ≤ 0.028) values were lower in PRLs compared to nPRLs, but there were no differences in PSR and R_1f (p ≥ 0.824) values between peri-PRLs and peri-nPRLs NAWM ROIs. PRL+ pwMS had similar PSR and R_1f (p ≥ 0.267) of the whole brain NAWM, similar WM lesions PSR (p = 0.764) but lower R_1f (p = 0.030) values.

Conclusions: In the early stages of MS, there is no association between PRLs and surrounding NAWM degree of injury.

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慢性活动性病变与白质疾病之间的关系：一项7特斯拉成像研究

背景：顺磁边缘病变（prl）与周围正常出现的白质（NAWM）疾病之间的关系，可能有助于prl与临床损害之间的关联，尚未得到充分探讨。目的：探讨prl是否与ms早期更严重的NAWM损伤相关。方法：对68例新诊断患者进行敏感性加权成像（SWI）检测prl。每个PRL与来自同一参与者的对侧非PRL （nPRL）配对。提取定量磁化转移成像所得的大分子与自由池大小比（PSR）和自由池松弛率（R1f）值，比较PRL与nprl、PRL与nprl周围的NAWM、PRL+与PRL- MS全脑WM病变与NAWM （pwMS）之间的差异。结果：prl患者的PSR和R1f值低于nprl患者（p≤0.028），但peri- prl患者与peri- nprl患者的NAWM roi之间PSR和R1f值无差异（p≥0.824）。PRL+ pwMS与全脑NAWM的PSR和R1f相似（p≥0.267），WM病变PSR相似（p = 0.764）， R1f较低（p = 0.030）。结论：MS早期prl与周围NAWM损伤程度无相关性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Annals of Clinical and Translational Neurology Medicine-Neurology (clinical)

CiteScore

9.10

自引率

1.90%

发文量

218

审稿时长

8 weeks

期刊介绍： Annals of Clinical and Translational Neurology is a peer-reviewed journal for rapid dissemination of high-quality research related to all areas of neurology. The journal publishes original research and scholarly reviews focused on the mechanisms and treatments of diseases of the nervous system; high-impact topics in neurologic education; and other topics of interest to the clinical neuroscience community.