The China Brain Multi-omics Atlas Project (CBMAP)

IF 10.1 1区医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Molecular Psychiatry Pub Date : 2025-09-15 DOI:10.1038/s41380-025-03250-3

Dan Zhou, Yuan Zhou, Zeyu Sun, Feiyang Ji, Dandan Zhang, Quan Wang, Yijun Ruan, Yongcheng Wang, Yimin Zhu, Xiaohui Sun, Mulin Jun Li, Changzheng Yuan, Kefu Liu, Lingyun Sun, Wenli Zhai, Jiayao Fan, Keqing Zhu, Wenying Qiu, Xiaoxin Yan, Chao Ma, Yi Shen, Aimin Bao, Weihua Yue, Yongyong Shi, Chao Chen, Jian Yang, Shumin Duan, Jing Zhang

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Abstract

The China Brain Multi-omics Atlas Project (CBMAP) aims to generate a comprehensive molecular reference map of over 1000 human brains (Phase I), spanning a broad age range and multiple regions in China, to address the underrepresentation of East Asian populations in brain research. By integrating genome, epigenome, transcriptome, proteome (including multiple post-translational modifications), and metabolome data, CBMAP is set to provide a rich and invaluable resource for investigating the molecular underpinnings of aging-related brain phenotypes and neuropsychiatric disorders. Leveraging high-throughput omics data and advanced technologies, such as spatial transcriptomics, proteomics, and single-nucleus 3D chromatin structure analysis, this atlas will serve as a crucial resource for the brain science community, illuminating disease mechanisms and enhancing the utility of data from genome-wide association studies (GWAS). CBMAP is also poised to accelerate drug discovery and precision medicine for brain disorders.

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中国脑多组学图谱计划（CBMAP）

中国脑多组学图谱项目（CBMAP）旨在生成超过1000个人类大脑的综合分子参考图谱（第一阶段），涵盖中国广泛的年龄范围和多个地区，以解决东亚人口在脑研究中的代表性不足问题。通过整合基因组、表观基因组、转录组、蛋白质组（包括多种翻译后修饰）和代谢组数据，CBMAP将为研究与衰老相关的脑表型和神经精神疾病的分子基础提供丰富而宝贵的资源。利用高通量组学数据和先进技术，如空间转录组学、蛋白质组学和单核三维染色质结构分析，该图谱将成为脑科学界的重要资源，阐明疾病机制并增强全基因组关联研究（GWAS）数据的实用性。CBMAP还将加速脑部疾病的药物发现和精准医疗。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Molecular Psychiatry 医学-精神病学

CiteScore

20.50

自引率

4.50%

发文量

459

审稿时长

4-8 weeks

期刊介绍： Molecular Psychiatry focuses on publishing research that aims to uncover the biological mechanisms behind psychiatric disorders and their treatment. The journal emphasizes studies that bridge pre-clinical and clinical research, covering cellular, molecular, integrative, clinical, imaging, and psychopharmacology levels.