Violeta Mauriz-Barreiro, Alberto Ruano-Raviña, Rocío Ferreiro-Iglesias, Iria Bastón-Rey, Cristina Calviño-Suárez, Laura Nieto-García, Sol Porto-Silva, Xurxo Martínez-Seara, Lucía Martín-Gisbert, J Enrique Domínguez-Muñoz, Manuel Barreiro-de Acosta
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引用次数: 0
Abstract
Background: Inflammatory bowel disease (IBD) develops from a dysregulated immune response influenced by environmental exposures. Radon, a radioactive gas, has known biological effects, but its role in IBD remains unexplored.
Objectives: To examine the association between residential radon exposure and the risk and clinical course of IBD.
Design: A case-control study with 1-year prospective follow-up of cases.
Methods: We included 178 newly diagnosed IBD patients and 178 age- and sex-matched controls in Santiago de Compostela, Spain, from June 2020 to September 2023. Residential radon levels were measured using passive detectors for 3 months. Outcomes included IBD diagnosis, disease extent, hospitalizations, and flares. Logistic regression was used to estimate odds ratios adjusted for age and sex.
Results: Median residential radon was 144.5 Bq/m3 in IBD cases and 189.5 Bq/m3 in controls. Higher radon levels were associated with reduced odds of IBD (OR 0.5 for 100-299 and >299 Bq/m3 vs 0-99 Bq/m3). No significant association was found between radon levels and hospitalizations or flares. Among ulcerative colitis patients, higher radon was linked to more extensive disease.
Conclusion: Higher residential radon exposure might be inversely associated with IBD risk. However, it does not appear to influence disease progression. Further studies are needed to confirm these findings, since this is the first study on this topic, and chance or selection bias might be present.
期刊介绍：
Therapeutic Advances in Gastroenterology is an open access journal which delivers the highest quality peer-reviewed original research articles, reviews, and scholarly comment on pioneering efforts and innovative studies in the medical treatment of gastrointestinal and hepatic disorders. The journal has a strong clinical and pharmacological focus and is aimed at an international audience of clinicians and researchers in gastroenterology and related disciplines, providing an online forum for rapid dissemination of recent research and perspectives in this area.
The editors welcome original research articles across all areas of gastroenterology and hepatology.
The journal publishes original research articles and review articles primarily. Original research manuscripts may include laboratory, animal or human/clinical studies – all phases. Letters to the Editor and Case Reports will also be considered.
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