Occurrence and Risk Factors for Unplanned Central Venous Catheter Removal in Critically Ill Patients: A Multicenter Cohort Study.

IF 2.3 Q1 NURSING
Nursing Research and Practice Pub Date : 2025-09-04 eCollection Date: 2025-01-01 DOI:10.1155/nrp/7640284
Xiaofeng He, Chunlei Li, Zhe Wang, Mayi Yang, Tianjun Zhou, Ying Gu, Yuxia Zhang, Wenchao Wang, Wenyan Pan, Yan Hu
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引用次数: 0

Abstract

Background: Central venous catheters (CVCs) are crucial for critically ill patients but pose risks of complications and unplanned removal, which can interrupt treatment, prolong hospital stays, and increase mortality. This investigation sought to examine the occurrence and risk factors for unplanned CVC removal among intensive care patients in China. Methods: A multicenter cohort study was conducted across 22 public tertiary hospitals throughout China, from September 4, 2023, to February 29, 2024, enrolling critically ill patients with CVCs. Cox proportional hazards regression models were used to assess the risk factors for unplanned CVC removal. Results: The study comprised a total of 2680 first-time CVC insertion events (one per patient) in critically ill patients. 1151 (42.95%) CVCs were removed; most (n = 832, 31.04%) were elective. A total of 153 CVCs were removed prematurely (5.71%; 95% CI: 4.84-6.68), and infection-related complication was the leading cause (n = 124, 4.63%; 95% CI: 3.85-5.50; 5.26 per 1000 CVC days). Independent risk factors included male gender (HR, 2.04; 95% CI: 1.40-2.99; p < 0.001), neurological disorders (HR, 2.41; 95% CI: 1.50-3.86; p < 0.001), and mechanical ventilation (HR, 1.71; 95% CI: 1.09-2.70; p=0.02), while urgent insertion reduced the risk (HR, 0.52; 95% CI: 0.29-0.92; p=0.02). In subgroup analysis, diagnosis with neurological disorders (HR, 2.31; 95% CI 1.40-3.81, p=0.001), and urgent CVC insertion (HR, 0.41; 95% CI 0.21-0.82, p=0.01) were significantly associated with unplanned CVC removal in males but not in females (p > 0.05). No significant interactions were found between gender and diagnosis, mechanical ventilation, or urgent insertion (all p > 0.05). Conclusions: Unplanned CVC removal occurred in 5.71% of cases, primarily due to infection. Identified risk factors (male gender, neurological disorders, and mechanical ventilation) and protective factors (urgent insertion) highlight targets for preventive strategies in critical care.

Abstract Image

危重病人意外中心静脉导管拔除的发生及危险因素:一项多中心队列研究。
背景:中心静脉导管(CVCs)对危重患者至关重要,但存在并发症和意外移除的风险,可能会中断治疗,延长住院时间,并增加死亡率。本研究旨在探讨中国重症监护患者非计划CVC切除的发生率和危险因素。方法:于2023年9月4日至2024年2月29日在全国22所公立三级医院开展多中心队列研究,纳入危重cvc患者。采用Cox比例风险回归模型评估非计划CVC切除的危险因素。结果:该研究共包括2680例危重患者首次CVC插入事件(每位患者1例)。切除cvc 1151例(42.95%);大多数(n = 832, 31.04%)是选择性的。153例CVC过早切除(5.71%;95% CI: 4.84-6.68),感染相关并发症是主要原因(n = 124, 4.63%; 95% CI: 3.85-5.50; 5.26 / 1000 CVC天)。独立危险因素包括男性(HR, 2.04; 95% CI: 1.40-2.99; p < 0.001)、神经系统疾病(HR, 2.41; 95% CI: 1.50-3.86; p < 0.001)和机械通气(HR, 1.71; 95% CI: 1.09-2.70; p=0.02),而紧急插入可降低风险(HR, 0.52; 95% CI: 0.29-0.92; p=0.02)。在亚组分析中,诊断为神经系统疾病(HR, 2.31; 95% CI 1.40-3.81, p=0.001)和紧急CVC插入(HR, 0.41; 95% CI 0.21-0.82, p=0.01)与男性非计划CVC切除显著相关,但与女性无关(p > 0.05)。性别与诊断、机械通气或紧急插入之间无显著相互作用(均p < 0.05)。结论:CVC意外切除占5.71%,主要原因是感染。已确定的危险因素(男性、神经系统疾病和机械通气)和保护因素(紧急插入)突出了重症监护预防策略的目标。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
2.90
自引率
0.00%
发文量
21
审稿时长
19 weeks
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