Prognosis of patients with coronavirus disease with or without anosmia: A systematic review.

Q3 Nursing

Malaysian Family Physician Pub Date : 2025-08-16 eCollection Date: 2025-01-01 DOI:10.51866/rv.672

Nabeel Ibraheem Jaafar Albazah, Jie Sin Tiong, Muruganand Yoshana, Azma Aishath, Yu Tzong Yeo, Sherreen Elhariri

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引用次数: 0

Abstract

Introduction: According to numerous research, anosmia has been reported more frequently as one of coronavirus disease (COVID-19) symptoms. However, whether anosmia is a relevant prognostic factor of COVID-19 outcomes is still unknown. A systematic review and meta-analysis were conducted to evaluate the relationship between anosmia and COVID-19 prognosis.

Methods: PubMed, PubMed Central, Google Scholar and the WHO COVID-19 Research Database were scanned for published literature from September 2021 to December 2022 about the prognosis of patients positive for COVID-19 with anosmia. 'COVID-19' and 'prognosis' were among the search terms used. Pooled estimates of odds ratios (ORs) were then calculated by comparing patients with and without anosmia in terms of intensive care unit (ICU) admission and death.

Results: A total of 16 full-text articles were included in this systematic review. There were a total of 40 deaths among the patients with olfactory dysfunction and 1681 deaths among those without olfactory dysfunction, with an OR of 0.19 (95% confidence interval: 0.10, 0.34; P<0.0001), indicating that the patients with COVID-19 with olfactory dysfunction had a decreased mortality rate.

Conclusion: The good prognosis of patients with COVID-19 with anosmia is demonstrated in our study by the low mortality rate in those with anosmia. However, there is no association between the prognosis and ICU admission among patients with COVID-19 with anosmia.

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冠状病毒病伴或不伴嗅觉丧失患者的预后：一项系统综述

根据大量研究，嗅觉缺失被报道为冠状病毒病（COVID-19）的症状之一。然而，嗅觉缺失是否是COVID-19预后的相关预后因素尚不清楚。通过系统回顾和荟萃分析来评估嗅觉缺失与COVID-19预后的关系。方法：扫描PubMed、PubMed Central、谷歌Scholar和WHO COVID-19研究数据库，检索2021年9月至2022年12月关于COVID-19阳性嗅觉缺失患者预后的已发表文献。“COVID-19”和“预后”是使用的搜索词。然后通过比较有和没有嗅觉缺失的患者在重症监护病房（ICU）入院和死亡方面的情况来计算优势比（ORs）的汇总估计。结果：本系统综述共纳入16篇全文文章。嗅觉功能障碍患者共死亡40例，无嗅觉功能障碍患者死亡1681例，OR为0.19（95%可信区间：0.10,0.34）。结论：嗅觉障碍患者的低死亡率证明了新冠肺炎嗅觉障碍患者预后良好。然而，新冠肺炎嗅觉缺失患者的预后与入住ICU无相关性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Malaysian Family Physician Medicine-Family Practice

CiteScore

1.20

自引率

0.00%

发文量

审稿时长

24 weeks

期刊介绍： The Malaysian Family Physician is the official journal of the Academy of Family Physicians of Malaysia. It is published three times a year. Circulation: The journal is distributed free of charge to all members of the Academy of Family Physicians of Malaysia. Complimentary copies are also sent to other organizations that are members of the World Organization of Family Doctors (WONCA).