Association of APOC1 levels and nutritional indices with clinicopathological features and prognostic value in patients with DLBCL.

IF 3.1 4区医学 Q3 ONCOLOGY

Tumori Pub Date : 2025-10-01 Epub Date: 2025-09-15 DOI:10.1177/03008916251362015

Wei Wang, Qiqiang Long

{"title":"Association of APOC1 levels and nutritional indices with clinicopathological features and prognostic value in patients with DLBCL.","authors":"Wei Wang, Qiqiang Long","doi":"10.1177/03008916251362015","DOIUrl":null,"url":null,"abstract":"Objective: This study aims to unravel the relationship between apolipoprotein C1 (APOC1) levels, prognostic nutritional index (PNI), and clinicopathological characteristics in patients with diffuse large B-cell lymphoma (DLBCL) and their prognostic predictive value.Methods: This study retrospectively analyzed clinical data from 55 DLBCL patients and 50 healthy screening volunteers. APOC1 levels and the PNI were compared between groups, along with their association with DLBCL's clinicopathological features. Patients were stratified into favorable and poor prognosis groups based on the International Prognostic Index (IPI), with APOC1 and PNI compared between subgroups. Kaplan-Meier curves were used to analyze the impact of high and low expression levels of APOC1 and PNI on progression-free survival (PFS) and overall survival (OS) in DLBCL patients. Multivariate logistic regression identified risk factors for poor prognosis, while Receiver Operating Characteristic (ROC) curves assessed the predictive value of APOC1 and PNI for DLBCL outcomes.Results: DLBCL patients had higher APOC1 levels and lower PNI than controls. Patients with advanced-stage (III-IV) disease showed significantly increased APOC1 and decreased PNI compared to early-stage (I-II) cases. DLBCL patients with high APOC1 expression and low PNI showed left-shifted PFS and OS curves (P < 0.05). Both elevated APOC1 and reduced PNI were independent risk factors for poor prognosis, with Area Under the Curve (AUC)s of 0.836 and 0.779, respectively. Their combined predictive value improved, suggesting potential utility in prognosis assessment.Conclusion: APOC1 levels and PNI are significantly correlated with higher disease risk in DLBCL, and their combined evaluation may help improve risk assessment.","PeriodicalId":23349,"journal":{"name":"Tumori","volume":" ","pages":"413-419"},"PeriodicalIF":3.1000,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Tumori","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1177/03008916251362015","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/9/15 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"ONCOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Objective: This study aims to unravel the relationship between apolipoprotein C1 (APOC1) levels, prognostic nutritional index (PNI), and clinicopathological characteristics in patients with diffuse large B-cell lymphoma (DLBCL) and their prognostic predictive value.

Methods: This study retrospectively analyzed clinical data from 55 DLBCL patients and 50 healthy screening volunteers. APOC1 levels and the PNI were compared between groups, along with their association with DLBCL's clinicopathological features. Patients were stratified into favorable and poor prognosis groups based on the International Prognostic Index (IPI), with APOC1 and PNI compared between subgroups. Kaplan-Meier curves were used to analyze the impact of high and low expression levels of APOC1 and PNI on progression-free survival (PFS) and overall survival (OS) in DLBCL patients. Multivariate logistic regression identified risk factors for poor prognosis, while Receiver Operating Characteristic (ROC) curves assessed the predictive value of APOC1 and PNI for DLBCL outcomes.

Results: DLBCL patients had higher APOC1 levels and lower PNI than controls. Patients with advanced-stage (III-IV) disease showed significantly increased APOC1 and decreased PNI compared to early-stage (I-II) cases. DLBCL patients with high APOC1 expression and low PNI showed left-shifted PFS and OS curves (P < 0.05). Both elevated APOC1 and reduced PNI were independent risk factors for poor prognosis, with Area Under the Curve (AUC)s of 0.836 and 0.779, respectively. Their combined predictive value improved, suggesting potential utility in prognosis assessment.

Conclusion: APOC1 levels and PNI are significantly correlated with higher disease risk in DLBCL, and their combined evaluation may help improve risk assessment.

查看原文本刊更多论文

DLBCL患者APOC1水平及营养指标与临床病理特征及预后价值的关系

目的：本研究旨在探讨弥漫大b细胞淋巴瘤（DLBCL）患者载脂蛋白C1 （APOC1）水平与预后营养指数（PNI）、临床病理特征的关系及其预后预测价值。方法：回顾性分析55例DLBCL患者和50名健康筛查志愿者的临床资料。比较各组间APOC1水平和PNI，以及它们与DLBCL临床病理特征的关系。根据国际预后指数（IPI）将患者分为预后良好组和预后不良组，并比较各亚组之间的APOC1和PNI。采用Kaplan-Meier曲线分析apop1和PNI高、低表达水平对DLBCL患者无进展生存期（PFS）和总生存期（OS）的影响。多因素logistic回归确定预后不良的危险因素，而受试者工作特征（ROC）曲线评估apop1和PNI对DLBCL预后的预测价值。结果：DLBCL患者的APOC1水平高于对照组，PNI水平低于对照组。与早期（I-II）患者相比，晚期（III-IV）患者的APOC1显著升高，PNI显著降低。apop1高表达、PNI低的DLBCL患者PFS和OS曲线左移（P < 0.05）。apop1升高和PNI降低均为预后不良的独立危险因素，曲线下面积（Area Under the Curve， AUC）s分别为0.836和0.779。两者的综合预测价值提高，提示在预后评估中具有潜在的应用价值。结论：apop1水平和PNI水平与DLBCL患者患病风险升高有显著相关性，两者联合评价有助于提高风险评估水平。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Tumori 医学-肿瘤学

CiteScore

3.50

自引率

0.00%

发文量

审稿时长

6 months

期刊介绍： Tumori Journal covers all aspects of cancer science and clinical practice with a strong focus on prevention, translational medicine and clinically relevant reports. We invite the publication of randomized trials and reports on large, consecutive patient series that investigate the real impact of new techniques, drugs and devices inday-to-day clinical practice.