Comparative Analysis of Patient-Reported Outcomes in Chronic Pruritus: Patients with Chronic Liver or Kidney Diseases Exhibit Higher Psychological Distress than Those with Atopic Dermatitis.
Svenja Royeck, Christian Mess, Angelika Weigel, Bernd Löwe, Anne Toussaint, Christoph Schramm, Meike Shedden Mora, Tobias B Huber, Claudia Zeidler, Felix Witte, Matthias Augustin, Konstantin Agelopoulos, Henning Wiegmann, Johannes B Oehm, Stefan W Schneider, Sonja Ständer
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Abstract
Introduction: Chronic pruritus (CP; lasting ≥ 6 weeks) is a prevalent symptom with diverse underlying conditions, including chronic liver diseases (CLD), chronic kidney diseases (CKD) and atopic dermatitis (AD). CP is linked to a substantial physical, psychological and socioeconomic burden. Despite guideline-recommend therapies, there remains a lack of comprehensive understanding regarding the specific needs, treatment goals and patient-reported outcomes (PRO) of patients with CP across these aetiologies.
Methods: To address this gap, this retrospective cohort study analysed anonymized electronic health records from a specialized pruritus centre in Germany, focusing on three matched sub-cohorts, which were compiled from a total cohort of 1998 patients with CLD, CKD and AD to systematically compare disease burden, and treatment priorities.
Results: Patients with CLD and CKD exhibited significantly higher psychological distress compared to patients with AD, while patients with AD demonstrated greater quality of life impairment. Treatment goals were largely aligned across all patient groups, with symptom relief, diagnostic clarity and confidence in therapy emerging as top priorities. Significant correlations between patient needs, QoL impairment, levels of anxiety and depression and pruritus intensity were observed across all sub-cohorts.
Conclusions: These results highlight the need for holistic, patient-centred management strategies that address both the physical and psychological aspects of CP.
期刊介绍：
Dermatology and Therapy is an international, open access, peer-reviewed, rapid publication journal (peer review in 2 weeks, published 3–4 weeks from acceptance). The journal is dedicated to the publication of high-quality clinical (all phases), observational, real-world, and health outcomes research around the discovery, development, and use of dermatological therapies. Studies relating to diagnosis, pharmacoeconomics, public health and epidemiology, quality of life, and patient care, management, and education are also encouraged.
Areas of focus include, but are not limited to all clinical aspects of dermatology, such as skin pharmacology; skin development and aging; prevention, diagnosis, and management of skin disorders and melanomas; research into dermal structures and pathology; and all areas of aesthetic dermatology, including skin maintenance, dermatological surgery, and lasers.
The journal is of interest to a broad audience of pharmaceutical and healthcare professionals and publishes original research, reviews, case reports/case series, trial protocols, and short communications. Dermatology and Therapy will consider all scientifically sound research be it positive, confirmatory or negative data. Submissions are welcomed whether they relate to an International and/or a country-specific audience, something that is crucially important when researchers are trying to target more specific patient populations. This inclusive approach allows the journal to assist in the dissemination of quality research, which may be considered of insufficient interest by other journals. The journal appeals to a global audience and receives submissions from all over the world.
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