Preoperative red blood cell transfusion improves treatment response and survival in patients with locally advanced esophageal cancer and iron deficiency anemia.
Jia Dai, Yuzhi Kang, Rong Fu, Li Yan, Yiyu Wang, Lin Li
{"title":"Preoperative red blood cell transfusion improves treatment response and survival in patients with locally advanced esophageal cancer and iron deficiency anemia.","authors":"Jia Dai, Yuzhi Kang, Rong Fu, Li Yan, Yiyu Wang, Lin Li","doi":"10.62347/ZKZM8986","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Locally advanced esophageal cancer presents significant treatment challenges, with iron deficiency anemia (IDA) potentially hindering the efficacy of neoadjuvant chemotherapy. This study aimed to evaluate the effect of preoperative red blood cell transfusion on tumor progression and chemotherapy response in patients with IDA.</p><p><strong>Methods: </strong>A retrospective cohort study was conducted at Shaanxi Provincial Cancer Hospital, involving 228 patients with locally advanced esophageal cancer and IDA, from August 2015 to August 2021. Patients were divided into two groups: 106 patients received preoperative red blood cell transfusions, and 122 did not. All patients underwent a standardized chemotherapy regimen followed by surgery. Hematological, immunological, and biochemical parameters, as well as chemotherapy-related adverse events, and survival outcomes were analyzed.</p><p><strong>Results: </strong>Preoperative transfusion significantly increased hemoglobin (Hb) levels (P < 0.05), enhanced immunological profiles (e.g., NK/T cell activity; P < 0.05), and reduced systemic inflammation (e.g., CRP; P < 0.05) after chemotherapy and operation. Overall survival and progression-free survival were notably better in the transfusion group (P = 0.002 and P = 0.012, respectively).</p><p><strong>Conclusion: </strong>Preoperative red blood cell transfusion improves hematological and immunological parameters and enhances survival outcomes in patients with locally advanced esophageal cancer and IDA.</p>","PeriodicalId":7437,"journal":{"name":"American journal of cancer research","volume":"15 8","pages":"3588-3602"},"PeriodicalIF":2.9000,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12432581/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"American journal of cancer research","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.62347/ZKZM8986","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"ONCOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Background: Locally advanced esophageal cancer presents significant treatment challenges, with iron deficiency anemia (IDA) potentially hindering the efficacy of neoadjuvant chemotherapy. This study aimed to evaluate the effect of preoperative red blood cell transfusion on tumor progression and chemotherapy response in patients with IDA.
Methods: A retrospective cohort study was conducted at Shaanxi Provincial Cancer Hospital, involving 228 patients with locally advanced esophageal cancer and IDA, from August 2015 to August 2021. Patients were divided into two groups: 106 patients received preoperative red blood cell transfusions, and 122 did not. All patients underwent a standardized chemotherapy regimen followed by surgery. Hematological, immunological, and biochemical parameters, as well as chemotherapy-related adverse events, and survival outcomes were analyzed.
Results: Preoperative transfusion significantly increased hemoglobin (Hb) levels (P < 0.05), enhanced immunological profiles (e.g., NK/T cell activity; P < 0.05), and reduced systemic inflammation (e.g., CRP; P < 0.05) after chemotherapy and operation. Overall survival and progression-free survival were notably better in the transfusion group (P = 0.002 and P = 0.012, respectively).
Conclusion: Preoperative red blood cell transfusion improves hematological and immunological parameters and enhances survival outcomes in patients with locally advanced esophageal cancer and IDA.
期刊介绍：
The American Journal of Cancer Research (AJCR) (ISSN 2156-6976), is an independent open access, online only journal to facilitate rapid dissemination of novel discoveries in basic science and treatment of cancer. It was founded by a group of scientists for cancer research and clinical academic oncologists from around the world, who are devoted to the promotion and advancement of our understanding of the cancer and its treatment. The scope of AJCR is intended to encompass that of multi-disciplinary researchers from any scientific discipline where the primary focus of the research is to increase and integrate knowledge about etiology and molecular mechanisms of carcinogenesis with the ultimate aim of advancing the cure and prevention of this increasingly devastating disease. To achieve these aims AJCR will publish review articles, original articles and new techniques in cancer research and therapy. It will also publish hypothesis, case reports and letter to the editor. Unlike most other open access online journals, AJCR will keep most of the traditional features of paper print that we are all familiar with, such as continuous volume, issue numbers, as well as continuous page numbers to retain our comfortable familiarity towards an academic journal.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
