Clinical characteristics and prognostic value of serological markers in pancreatic neuroendocrine tumors: a single-center retrospective study.

IF 2.9 3区医学 Q2 ONCOLOGY

American journal of cancer research Pub Date : 2025-08-15 eCollection Date: 2025-01-01 DOI:10.62347/HTDK5833

Renrui Wan, Junfeng Wang, Ping Xie, Xiaochang Wu, Kun Guo

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引用次数: 0

Abstract

Objective: To investigate the clinical characteristics, diagnostic methods, treatment strategies and prognostic factors of pancreatic neuroendocrine tumors (pNETs).

Methods: A retrospective analysis was conducted on 43 pNET patients treated at Huzhou Central Hospital from January 2003 to December 2023. The data included age, gender, function, tumor location, tumor size, pathological characteristics, lymph nodes, metastasis, and treatment. Association of these factors with pNET prognosis was proven by univariate analysis and multivariate analysis.

Results: The incidence of G3 tumors in this group of advanced patients was relatively high (P=0.001). Meanwhile, elevated CA125 was commonly seen in the advanced stage (P=0.045), and surgeries occurred more frequently in the early stage (P=0.003). In addition, the positive expression of CD56 in low-grade tumors was relatively high (P=0.014). The incidence of non-functional tumors larger than 2 cm was high (P=0.015). Univariate Cox regression revealed that tumor size >2 cm, G3 grade, liver metastasis, advanced stage, lymph node metastasis and invasion were risk factors. Multivariate analysis revealed that G3 grade, liver metastasis and advanced stage were independent influencing factors for disease progression.

Conclusion: pNETs are heterogeneous tumors. Pathological grade, metastatic status, and serological markers may assist in diagnosis and prognosis assessment, aiding individualized clinical management.

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胰腺神经内分泌肿瘤血清学标志物的临床特征及预后价值：一项单中心回顾性研究。

目的：探讨胰腺神经内分泌肿瘤的临床特点、诊断方法、治疗策略及影响预后的因素。方法：对2003年1月至2023年12月湖州市中心医院收治的43例pNET患者进行回顾性分析。资料包括年龄、性别、功能、肿瘤位置、肿瘤大小、病理特征、淋巴结、转移和治疗情况。通过单因素分析和多因素分析证实了这些因素与pNET预后的相关性。结果：本组晚期患者G3肿瘤发生率较高（P=0.001）。CA125升高常见于晚期（P=0.045），手术多发于早期（P=0.003）。此外，CD56在低级别肿瘤中的阳性表达相对较高（P=0.014）。大于2 cm的非功能性肿瘤发生率较高（P=0.015）。单因素Cox回归分析显示，肿瘤大小> ~ 2cm、G3分级、肝转移、晚期、淋巴结转移及侵袭是其危险因素。多因素分析显示，G3分级、肝转移和晚期是影响病情进展的独立因素。结论：pNETs是异质肿瘤。病理分级、转移状态和血清学指标可能有助于诊断和预后评估，有助于个体化临床管理。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

American journal of cancer research ONCOLOGY-

自引率

3.80%

发文量

263

期刊介绍： The American Journal of Cancer Research (AJCR) (ISSN 2156-6976), is an independent open access, online only journal to facilitate rapid dissemination of novel discoveries in basic science and treatment of cancer. It was founded by a group of scientists for cancer research and clinical academic oncologists from around the world, who are devoted to the promotion and advancement of our understanding of the cancer and its treatment. The scope of AJCR is intended to encompass that of multi-disciplinary researchers from any scientific discipline where the primary focus of the research is to increase and integrate knowledge about etiology and molecular mechanisms of carcinogenesis with the ultimate aim of advancing the cure and prevention of this increasingly devastating disease. To achieve these aims AJCR will publish review articles, original articles and new techniques in cancer research and therapy. It will also publish hypothesis, case reports and letter to the editor. Unlike most other open access online journals, AJCR will keep most of the traditional features of paper print that we are all familiar with, such as continuous volume, issue numbers, as well as continuous page numbers to retain our comfortable familiarity towards an academic journal.