TRPV2 Regulates Function of Human Neutrophil Granulocytes

IF 4.2 2区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

The FASEB Journal Pub Date : 2025-09-15 DOI:10.1096/fj.202501585RR

Anna S. Heinemann, Tabea C. Fricke, Christine Herzog, Frank G. Echtermeyer, Andreas Leffler

引用次数: 0

Abstract

Neutrophils play a vital role in human immune defense, and their dysregulation can cause collateral damage in sepsis and autoimmune diseases. We provide evidence for the involvement of the transient receptor potential vanilloid 2 (TRPV2) in cytokine expression and transmigration in human neutrophils as well as in HL60 cells. These data identify TRPV2 as a candidate target for novel therapeutics regulating neutrophil activity.

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TRPV2调控人中性粒细胞功能

中性粒细胞在人体免疫防御中起着至关重要的作用，它们的失调会导致败血症和自身免疫性疾病的附带损害。我们为瞬时受体电位香草样蛋白2 （TRPV2）参与人中性粒细胞和HL60细胞中细胞因子的表达和转运提供了证据。这些数据确定TRPV2是调节中性粒细胞活性的新疗法的候选靶点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

The FASEB Journal 生物-生化与分子生物学

CiteScore

9.20

自引率

2.10%

发文量

6243

审稿时长

3 months

期刊介绍： The FASEB Journal publishes international, transdisciplinary research covering all fields of biology at every level of organization: atomic, molecular, cell, tissue, organ, organismic and population. While the journal strives to include research that cuts across the biological sciences, it also considers submissions that lie within one field, but may have implications for other fields as well. The journal seeks to publish basic and translational research, but also welcomes reports of pre-clinical and early clinical research. In addition to research, review, and hypothesis submissions, The FASEB Journal also seeks perspectives, commentaries, book reviews, and similar content related to the life sciences in its Up Front section.