Nucleophilic addition of sulfoxonium ylides to hypervalent iodine diazo compounds as N-terminal electrophiles: direct access to novel functionalized hydrazones

IF 4.7 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Chemistry Frontiers Pub Date : 2025-09-15 DOI:10.1039/d5qo00885a

Varun Anand, Ruchir Kant, Namrata Rastogi

引用次数: 0

Abstract

A catalyst and additive-free nucleophilic addition of sulfoxonium ylides to hypervalent iodine diazo reagents as N-terminal electrophiles has been developed. The reaction not only leads to a facile access to highly functionalized hydrazones but also significantly advances the understanding of hitherto unexplored terminal N-electrophilicity in HIDCs. The operational simplicity, wide substrate scope, high product yields and mild conditions are notable features of the methodology.

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在高价碘重氮化合物上作为n端亲电试剂的亚砜鎓化物的亲核加成：直接获得新的功能化腙

在高价碘重氮试剂的n端亲电试剂上，建立了一种无催化剂和助剂的亚砜酰亚砜的亲核加成反应。该反应不仅可以方便地获得高度功能化的腙，而且还极大地促进了对迄今为止尚未探索的hdc末端n亲电性的理解。该方法具有操作简单、衬底范围广、产品收率高、条件温和等特点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Organic Chemistry Frontiers CHEMISTRY, ORGANIC-

CiteScore

7.90

自引率

11.10%

发文量

686

审稿时长

1 months

期刊介绍： Organic Chemistry Frontiers is an esteemed journal that publishes high-quality research across the field of organic chemistry. It places a significant emphasis on studies that contribute substantially to the field by introducing new or significantly improved protocols and methodologies. The journal covers a wide array of topics which include, but are not limited to, organic synthesis, the development of synthetic methodologies, catalysis, natural products, functional organic materials, supramolecular and macromolecular chemistry, as well as physical and computational organic chemistry.