Vasoactive Intestinal Peptide: Another Player in Adipose Tissue Blood Flow Regulation?

IF 2 4区医学 Q3 HEMATOLOGY

Microcirculation Pub Date : 2025-09-14 DOI:10.1111/micc.70026

Richard Sotorník, Julie Ménard, Pascal Brassard, Maude Gagnon-Auger, Jean-Patrice Baillargeon, Jean-Luc Ardilouze

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引用次数: 0

Abstract

Objectives

In healthy people, adipose tissue blood flow (ATBF) rises postprandially; however, in one third of them, this response is altered. These people are characterized by prolonged postprandial lipemia and higher cardiometabolic risk. Vasoactive intestinal peptide (VIP) is a gut neurotransmitter with a vasodilatory effect. The aim of the study was to assess the role of VIP in ATBF regulation and its postprandial blunting.

Methods

Plasma VIP and ATBF (¹³³Xenon washout technique) were measured during a 75 g oral glucose load in 16 healthy participants. ATBF was monitored in 12 individuals during in situ microinfusion of incremental doses of VIP (10⁻⁷, 10⁻⁶, 10⁻⁵ mol L⁻¹).

Results

Oral glucose induced no change in plasma VIP. Post-glucose ATBF measures identified 7 non-responders (peak blood flow < 50% of fasting values) and 9 responders. Compared to baseline (2.50 [1.96–3.59] mL·100 g⁻¹ min⁻¹), local microinfusion of VIP increased ATBF dose-dependently: 2.67 [2.18–3.89]; 4.35 [3.33–4.65]; and 7.91 [6.59–9.88] mL·100 g⁻¹ min⁻¹ (p < 0.0001) with a non-significant lower response to VIP in non-responders.

Conclusions

Our findings show a potent vasodilatory effect of VIP in adipose tissue and suggest that individuals with a blunted ATBF response to glucose load have a lower response. Whether the local unresponsiveness to VIP participates in this non-responder status has to be confirmed in larger studies.

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血管活性肠肽：脂肪组织血流调节的另一个参与者？

健康人群餐后脂肪组织血流量（ATBF）升高；然而，在其中三分之一的人身上，这种反应发生了变化。这些人的特点是餐后血脂延长，心脏代谢风险较高。血管活性肠肽（VIP）是一种具有血管舒张作用的肠道神经递质。本研究的目的是评估VIP在ATBF调节及其餐后钝化中的作用。方法测定16例健康受试者在75 g口服葡萄糖负荷时血浆VIP和ATBF（133氙冲洗技术）。在原位微量注射增加剂量的VIP（10−7、10−6、10−5 mol L−1）期间，对12例个体的ATBF进行监测。结果口服葡萄糖对血浆VIP无明显影响。葡萄糖后ATBF测量确定了7个无反应（峰值血流量&禁食值的50%）和9个反应。与基线（2.50 [1.96-3.59]mL·100 g−1 min−1）相比，局部微量注射VIP使ATBF呈剂量依赖性增加：2.67 [2.18-3.89]；4.35 (3.33 - -4.65);7.91 [6.59-9.88] mL·100 g−1 min−1 (p < 0.0001)，无应答者对VIP的反应不显著降低。结论：我们的研究结果显示VIP在脂肪组织中具有强大的血管扩张作用，并且表明ATBF对葡萄糖负荷反应迟钝的个体反应较低。局部对VIP的无反应是否参与了这种无反应状态，还有待于更大规模的研究来证实。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Microcirculation 医学-外周血管病

CiteScore

5.00

自引率

4.20%

发文量

审稿时长

6-12 weeks

期刊介绍： The journal features original contributions that are the result of investigations contributing significant new information relating to the vascular and lymphatic microcirculation addressed at the intact animal, organ, cellular, or molecular level. Papers describe applications of the methods of physiology, biophysics, bioengineering, genetics, cell biology, biochemistry, and molecular biology to problems in microcirculation. Microcirculation also publishes state-of-the-art reviews that address frontier areas or new advances in technology in the fields of microcirculatory disease and function. Specific areas of interest include: Angiogenesis, growth and remodeling; Transport and exchange of gasses and solutes; Rheology and biorheology; Endothelial cell biology and metabolism; Interactions between endothelium, smooth muscle, parenchymal cells, leukocytes and platelets; Regulation of vasomotor tone; and Microvascular structures, imaging and morphometry. Papers also describe innovations in experimental techniques and instrumentation for studying all aspects of microcirculatory structure and function.