Vestibular-related dizziness duration and cognitive deficits in older adults

IF 6.8 Q1 CLINICAL NEUROLOGY

Alzheimer''s and Dementia: Translational Research and Clinical Interventions Pub Date : 2025-09-15 DOI:10.1002/trc2.70153

Xiaobao Ma, Jiali Shen, Wei Wang, Lu Wang, Yulian Jin, Maoli Duan, Qing Zhang, Jun Yang, Jianyong Chen

{"title":"Vestibular-related dizziness duration and cognitive deficits in older adults","authors":"Xiaobao Ma, Jiali Shen, Wei Wang, Lu Wang, Yulian Jin, Maoli Duan, Qing Zhang, Jun Yang, Jianyong Chen","doi":"10.1002/trc2.70153","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> OBJECTIVE</h3>\n \n <p>The objective of this study is to investigate the relationship between symptom duration of vestibular-related dizziness/vertigo and cognitive function in elderly patients, and to establish clinical guidance for assessing and intervening in vestibular-related cognitive impairments.</p>\n </section>\n \n <section>\n \n <h3> METHODS</h3>\n \n <p>This study included 100 elderly patients with vestibular dysfunction presenting dizziness, vertigo, or balance disorders, categorized into short-duration (<i>n</i> = 64) and long-duration (<i>n</i> = 36) groups based on symptom duration. A control group of 21 healthy elderly individuals was included. Cognitive assessments comprised P300 event-related potentials (latency/amplitude) and Montreal Cognitive Assessment (MoCA) with domain-specific analysis.</p>\n </section>\n \n <section>\n \n <h3> RESULTS</h3>\n \n <p>Significant between-group differences in P300 latency were observed (control vs short-duration vs long-duration: <i>p</i> < 0.001), whereas amplitude showed no difference (<i>p</i> = 0.817). MoCA total scores differed significantly across groups (<i>p</i> = 0.001), although abnormality rates were comparable (<i>p</i> = 0.093). Domain analysis revealed significant differences in visuospatial (<i>p</i> < 0.001) and abstract abilities (<i>p</i> = 0.005). Symptom duration correlated with: MoCA total (<i>R</i><sup>2</sup> = 0.113), visuospatial ability (<i>R</i><sup>2</sup> = 0.181), attention (<i>R</i><sup>2</sup> = 0.068), and orientation (<i>R</i><sup>2</sup> = 0.157). P300 latency correlated with: MoCA total (<i>R</i><sup>2</sup> = 0.141), visuospatial ability (<i>R</i><sup>2</sup> = 0.090), delayed recall (<i>R</i><sup>2</sup> = 0.112), and orientation (<i>R</i><sup>2</sup> = 0.082).</p>\n </section>\n \n <section>\n \n <h3> CONCLUSION</h3>\n \n <p>Prolonged vestibular-related dizziness/vertigo in elderly patients is associated with cognitive deficits, particularly in visuospatial and executive functions. P300 latency demonstrates greater sensitivity than both P300 amplitude and MoCA screening, suggesting that combined electrophysiological and neuropsychological assessment enhances early detection of vestibular-related cognitive impairment.</p>\n </section>\n \n <section>\n \n <h3> Highlights</h3>\n \n <div>\n <ul>\n \n <li>Long-duration vestibular-related dizziness or balance disorders are associated with a higher risk of cognitive impairment in elderly patients.</li>\n \n <li>Among early assessment tools, P300 latency proves more sensitive than both P300 amplitude and the Montreal Cognitive Assessment (MoCA) questionnaire.</li>\n \n <li>A combined evaluation using P300 latency and MoCA provides a more effective measure of how dizziness affects cognitive function in this population.</li>\n </ul>\n </div>\n </section>\n </div>","PeriodicalId":53225,"journal":{"name":"Alzheimer''s and Dementia: Translational Research and Clinical Interventions","volume":"11 3","pages":""},"PeriodicalIF":6.8000,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://alz-journals.onlinelibrary.wiley.com/doi/epdf/10.1002/trc2.70153","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Alzheimer''s and Dementia: Translational Research and Clinical Interventions","FirstCategoryId":"1085","ListUrlMain":"https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/trc2.70153","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

OBJECTIVE

The objective of this study is to investigate the relationship between symptom duration of vestibular-related dizziness/vertigo and cognitive function in elderly patients, and to establish clinical guidance for assessing and intervening in vestibular-related cognitive impairments.

METHODS

This study included 100 elderly patients with vestibular dysfunction presenting dizziness, vertigo, or balance disorders, categorized into short-duration (n = 64) and long-duration (n = 36) groups based on symptom duration. A control group of 21 healthy elderly individuals was included. Cognitive assessments comprised P300 event-related potentials (latency/amplitude) and Montreal Cognitive Assessment (MoCA) with domain-specific analysis.

RESULTS

Significant between-group differences in P300 latency were observed (control vs short-duration vs long-duration: p < 0.001), whereas amplitude showed no difference (p = 0.817). MoCA total scores differed significantly across groups (p = 0.001), although abnormality rates were comparable (p = 0.093). Domain analysis revealed significant differences in visuospatial (p < 0.001) and abstract abilities (p = 0.005). Symptom duration correlated with: MoCA total (R² = 0.113), visuospatial ability (R² = 0.181), attention (R² = 0.068), and orientation (R² = 0.157). P300 latency correlated with: MoCA total (R² = 0.141), visuospatial ability (R² = 0.090), delayed recall (R² = 0.112), and orientation (R² = 0.082).

CONCLUSION

Prolonged vestibular-related dizziness/vertigo in elderly patients is associated with cognitive deficits, particularly in visuospatial and executive functions. P300 latency demonstrates greater sensitivity than both P300 amplitude and MoCA screening, suggesting that combined electrophysiological and neuropsychological assessment enhances early detection of vestibular-related cognitive impairment.

Highlights

Long-duration vestibular-related dizziness or balance disorders are associated with a higher risk of cognitive impairment in elderly patients.
Among early assessment tools, P300 latency proves more sensitive than both P300 amplitude and the Montreal Cognitive Assessment (MoCA) questionnaire.
A combined evaluation using P300 latency and MoCA provides a more effective measure of how dizziness affects cognitive function in this population.

Abstract Image

查看原文本刊更多论文

老年人前庭相关头晕持续时间与认知缺陷

目的探讨老年患者前庭相关性头晕/眩晕症状持续时间与认知功能的关系，为评估和干预前庭相关性认知障碍提供临床指导。方法本研究纳入100例表现为头晕、眩晕或平衡障碍的老年前庭功能障碍患者，根据症状持续时间分为短期组（n = 64）和长期组（n = 36）。对照组为21名健康老年人。认知评估包括P300事件相关电位（潜伏期/振幅）和蒙特利尔认知评估（MoCA）以及特定领域分析。结果P300潜伏期组间差异显著（对照组、短时间潜伏期和长时间潜伏期：p <； 0.001），而振幅无差异（p = 0.817）。各组间MoCA总分差异显著（p = 0.001），但异常率具有可比性（p = 0.093）。领域分析显示，视觉空间（p < 0.001）和抽象能力（p = 0.005）存在显著差异。症状持续时间与MoCA总分（R2 = 0.113）、视觉空间能力（R2 = 0.181）、注意力（R2 = 0.068）、定向（R2 = 0.157）相关。P300潜伏期与MoCA总量（R2 = 0.141）、视觉空间能力（R2 = 0.090）、延迟回忆（R2 = 0.112）和定向（R2 = 0.082）相关。结论：老年患者前庭相关性头晕/眩晕伴认知功能障碍，尤其是视觉空间和执行功能障碍。P300潜伏期比P300振幅和MoCA筛查更敏感，表明电生理和神经心理学联合评估有助于前庭相关认知障碍的早期检测。在老年患者中，长期前庭相关的头晕或平衡障碍与认知障碍的高风险相关。在早期的评估工具中，P300潜伏期被证明比P300振幅和蒙特利尔认知评估（MoCA）问卷更敏感。使用P300潜伏期和MoCA的联合评估可以更有效地衡量眩晕如何影响这一人群的认知功能。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Alzheimer''s and Dementia: Translational Research and Clinical Interventions Medicine-Psychiatry and Mental Health

CiteScore

10.10

自引率

2.10%

发文量

134

审稿时长

10 weeks

期刊介绍： Alzheimer''s & Dementia: Translational Research & Clinical Interventions (TRCI) is a peer-reviewed, open access,journal from the Alzheimer''s Association®. The journal seeks to bridge the full scope of explorations between basic research on drug discovery and clinical studies, validating putative therapies for aging-related chronic brain conditions that affect cognition, motor functions, and other behavioral or clinical symptoms associated with all forms dementia and Alzheimer''s disease. The journal will publish findings from diverse domains of research and disciplines to accelerate the conversion of abstract facts into practical knowledge: specifically, to translate what is learned at the bench into bedside applications. The journal seeks to publish articles that go beyond a singular emphasis on either basic drug discovery research or clinical research. Rather, an important theme of articles will be the linkages between and among the various discrete steps in the complex continuum of therapy development. For rapid communication among a multidisciplinary research audience involving the range of therapeutic interventions, TRCI will consider only original contributions that include feature length research articles, systematic reviews, meta-analyses, brief reports, narrative reviews, commentaries, letters, perspectives, and research news that would advance wide range of interventions to ameliorate symptoms or alter the progression of chronic neurocognitive disorders such as dementia and Alzheimer''s disease. The journal will publish on topics related to medicine, geriatrics, neuroscience, neurophysiology, neurology, psychiatry, clinical psychology, bioinformatics, pharmaco-genetics, regulatory issues, health economics, pharmacoeconomics, and public health policy as these apply to preclinical and clinical research on therapeutics.