Epidemiology of Barrett's Neoplasia in Japan.

IF 3.6 3区 医学 Q2 GASTROENTEROLOGY & HEPATOLOGY
Digestion Pub Date : 2025-09-12 DOI:10.1159/000548362
Katsunori Iijima
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引用次数: 0

Abstract

Background: With a 50-year delay compared to Europe and the USA, esophageal adenocarcinoma (EAC) began to increase in Japan around 2010, and it is expected to continue rising over the next few decades. This 50-year discrepancy is primarily attributable to variations in the timing of the decline in Helicobacter pylori infection rates across the two regions, with the extent of obesity in Japan also exerting an influence on the projected increase in EAC. Currently, the incidence of EAC in Japan is approximately one-tenth to one-twentieth that observed in Europe and the USA. However, ongoing monitoring is essential to assess the potential for escalation of this cancer. Accurate estimation of the incidence of EAC in Barrett's esophagus (BE), a precancerous condition of EAC, is imperative for the establishment of appropriate endoscopic surveillance for early cancer detection.

Summary: The incidence of EAC in BE is largely determined by its length. In the Japanese population, BE with a length greater than 3 centimeters exhibits a high incidence of EAC and necessitates surveillance, while BE with a length less than 1 centimeter exhibits an exceptionally low incidence of EAC and is considered to require no surveillance. The challenge lies in determining the optimal approach for addressing BE with a length of 1-3 cm, which is observed in 5-15 percent of endoscopic examinees, necessitating careful consideration due to its significance.

Key message: Since the EAC risk of BE varies greatly depending on its length, the need for surveillance and inspection intervals for BE in Japan should be defined by its length.

巴雷特病流行病学;日本的肿瘤。
与欧洲和美国相比,日本的食管腺癌(EAC)在2010年左右开始增加,比欧洲和美国晚了50年,预计在未来几十年将继续上升。这50年的差异主要是由于两个地区幽门螺杆菌感染率下降的时间不同,日本的肥胖程度也对EAC的预测增长产生了影响。目前,日本的EAC发病率约为欧洲和美国的十分之一至二十分之一。然而,持续监测对于评估这种癌症升级的可能性至关重要。Barrett食管(EAC)是EAC的癌前病变,准确估计EAC的发生率对于建立适当的内镜监测以早期发现癌症至关重要。EAC在BE中的发生率很大程度上取决于其长度。在日本人群中,长度大于3厘米的BE发病率高,需要进行监测,而长度小于1厘米的BE发病率极低,不需要进行监测。挑战在于确定解决长度为1-3厘米的BE的最佳方法,在5- 15%的内窥镜检查患者中观察到,由于其重要性,需要仔细考虑。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Digestion
Digestion 医学-胃肠肝病学
CiteScore
7.90
自引率
0.00%
发文量
39
审稿时长
6-12 weeks
期刊介绍: ''Digestion'' concentrates on clinical research reports: in addition to editorials and reviews, the journal features sections on Stomach/Esophagus, Bowel, Neuro-Gastroenterology, Liver/Bile, Pancreas, Metabolism/Nutrition and Gastrointestinal Oncology. Papers cover physiology in humans, metabolic studies and clinical work on the etiology, diagnosis, and therapy of human diseases. It is thus especially cut out for gastroenterologists employed in hospitals and outpatient units. Moreover, the journal''s coverage of studies on the metabolism and effects of therapeutic drugs carries considerable value for clinicians and investigators beyond the immediate field of gastroenterology.
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