Oncological and functional outcomes of salvage surgery for local oropharyngeal cancer recurrence after primary Radiation±Chemotherapy

IF 2.4 4区医学 Q3 ONCOLOGY

Surgical Oncology-Oxford Pub Date : 2025-09-04 DOI:10.1016/j.suronc.2025.102276

Francisco Laxague , Naif Fnais , Dorsa Zabihi , Kevin Fung , Danielle MacNeil , Adrian Mendez , John Yoo , Pencilla Lang , Joe S. Mymryk , John W. Barrett , David A. Palma , Anthony C. Nichols

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引用次数: 0

Abstract

Background

We aimed to analyze the role of salvage surgery for local/locoregional OPSCC recurrences after primary radiotherapy ± chemotherapy (CRT).

Methods

From 1156 patients, we identified 38 patients undergoing salvage surgery for local/locoregional recurrences. We analyzed surgical and survival outcomes based on surgical approach and clinical variables.

Results

Thirty-eight patients underwent SS for a local/locoregional OPSCC recurrence. Patients undergoing SS experienced superior overall survival (3-year 62.1 % vs. 13 %; and OS: 5-year 34 % vs. 0 %; p < 0.01) and progression-free survival: 3-year 61.1 % vs. 0 %; and PFS: 5-year 28.6 % vs. 0 %; p < 0.01) compared with those undergoing non-surgical treatment. One year after the surgery, 12/27 surviving patients (44.4 %) were tracheostomy dependent, and 12/27 feeding tube dependent.

Conclusion

Salvage surgery for locoregional OPSCC recurrences after primary CRT is safe and feasible in selected patients. However, patients should be counselled about the possibility of long-term feeding tube and/or tracheostomy dependency post operatively.

查看原文本刊更多论文

初次放疗±化疗后局部口咽癌复发补救性手术的肿瘤和功能预后

背景：我们的目的是分析挽救性手术在初次放疗±化疗（CRT）后局部/局部区域OPSCC复发中的作用。方法从1156例患者中，我们确定了38例因局部/局部复发而接受补救性手术的患者。我们根据手术入路和临床变量分析手术和生存结果。结果38例局部/局部复发的OPSCC行SS治疗。接受SS治疗的患者总体生存率更高（3年62.1% vs. 13%； 5年OS: 34% vs. 0%; p < 0.01），无进展生存率：3年61.1% vs. 0%；PFS: 5年28.6% vs. 0%；P < 0.01)。术后1年存活患者中有12/27（44.4%）依赖气管造口，12/27依赖饲管。结论原发性CRT术后局部OPSCC复发的抢救手术是安全可行的。然而，应告知患者术后长期喂食管和/或气管造口依赖的可能性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Surgical Oncology-Oxford 医学-外科

CiteScore

4.50

自引率

0.00%

发文量

169

审稿时长

38 days

期刊介绍： Surgical Oncology is a peer reviewed journal publishing review articles that contribute to the advancement of knowledge in surgical oncology and related fields of interest. Articles represent a spectrum of current technology in oncology research as well as those concerning clinical trials, surgical technique, methods of investigation and patient evaluation. Surgical Oncology publishes comprehensive Reviews that examine individual topics in considerable detail, in addition to editorials and commentaries which focus on selected papers. The journal also publishes special issues which explore topics of interest to surgical oncologists in great detail - outlining recent advancements and providing readers with the most up to date information.