Retinal neurodegeneration and choroidal changes of early diabetes in peripapillary region detected by swept-source optical coherence tomography angiography

IF 2.7 4区医学 Q2 PERIPHERAL VASCULAR DISEASE

Microvascular research Pub Date : 2025-09-10 DOI:10.1016/j.mvr.2025.104867

Zhaoxia Zheng , Nianen Liu , Jianing Wang , Yue Zhang , Xiaoya Gu , Shuang Song , Xiaobing Yu

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Abstract

Purpose

This study was designed to evaluate peripapillary retinal nerve fiber layer (pRNFL) and choroidal alterations in diabetic patients without diabetic retinopathy (NDR), and further explore their association utilizing ultrawide-field swept-source optical coherence tomography angiography (UWF-SS-OCTA).

Methods

This cross-sectional study included 169 eyes of 169 NDR subjects and 54 eyes of 54 healthy controls. pRNFL, choroidal thickness and volume were compared and measured with UWF-SS-OCTA. The association between pRNFL and choroidal parameters was assessed with Spearman correlation analysis. Further multivariate linear regression analysis was performed to evaluate their relationship after adjusting for confounding factors.

Results

Compared with healthy controls, NDR patients showed reduced choroidal thickness and volume in the full range and several peripapillary subfields, while a statistical decrease of pRNFL was only detected in the inferior quadrant (P = 0.04). Regarding the distribution profiles in the peripapillary region, the choroid was thickest in the temporal region and thinnest in the inferior region, and a more prominent decrease compared with controls was found in the inferior region. Average pRNFL thickness was independently associated with full-range mean choroidal volume in multiple regression analysis (β = 0.16, P = 0.04).

Conclusion

As two early signs of DR, choroidal thinning could precede retinal neurodegeneration. Decreased choroidal thickness may account for the susceptibility of RNFL thinning.

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扫描源光学相干断层血管造影检测早期糖尿病乳头周围区视网膜神经变性和脉络膜改变

目的评价无糖尿病视网膜病变（NDR）的糖尿病患者乳头周围视网膜神经纤维层（pRNFL）和脉络膜改变，并利用超宽视场扫描源光学相干断层血管造影（UWF-SS-OCTA）进一步探讨两者之间的相关性。方法横断面研究包括169例NDR患者的169只眼和54例健康对照者的54只眼。用UWF-SS-OCTA比较测定pRNFL、脉络膜厚度和体积。采用Spearman相关分析评估pRNFL与脉络膜参数的关系。在调整混杂因素后，进一步进行多元线性回归分析来评估两者之间的关系。结果与健康对照组相比，NDR患者全范围及多个乳头周围亚野的脉络膜厚度和体积均减少，pRNFL仅在下象限有统计学意义上的减少（P = 0.04）。在乳头周围区域的分布剖面上，颞区脉络膜最厚，下区最薄，下区与对照组相比减少更为明显。在多元回归分析中，平均pRNFL厚度与全范围平均脉络膜体积独立相关（β = 0.16, P = 0.04）。结论脉络膜变薄是视网膜神经退行性变的两个早期征象。脉络膜厚度减少可能是RNFL变薄的原因。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Microvascular research 医学-外周血管病

CiteScore

6.00

自引率

3.20%

发文量

158

审稿时长

43 days

期刊介绍： Microvascular Research is dedicated to the dissemination of fundamental information related to the microvascular field. Full-length articles presenting the results of original research and brief communications are featured. Research Areas include: • Angiogenesis • Biochemistry • Bioengineering • Biomathematics • Biophysics • Cancer • Circulatory homeostasis • Comparative physiology • Drug delivery • Neuropharmacology • Microvascular pathology • Rheology • Tissue Engineering.