Temporal and topographic effects of longer auditory stimuli on slow oscillations during slow wave sleep

IF 4.9 2区医学 Q1 ENGINEERING, BIOMEDICAL

Biomedical Signal Processing and Control Pub Date : 2025-09-13 DOI:10.1016/j.bspc.2025.108649

Marek Piorecký , Filip Černý , Václava Piorecká , Daniela Dudysová , Jana Kopřivová

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引用次数: 0

Abstract

Closed-loop targeted memory reactivation (CL-TMR) is a novel method for precise targeting and reactivation of selective memories consolidated during sleep. Electrophysiologically, slow oscillations (SOs) are evoked, associated with increased depth of non-rapid eye movement (NREM) 3 sleep. We performed evoked response potential (ERP) analyses on NREM 3 sleep data collected during auditory stimulation with 300 ms sounds. SOs were further characterized using topographical mapping and Hjorth parameters, with trials categorized into upstate and downstate segments based on stimulation phase. Our findings revealed significant differences between spontaneous and evoked SOs in both topographical distribution and signal complexity. Upstate stimulations produced stronger responses in frontal and occipital regions, particularly around the P300 component, suggesting greater cognitive processing than downstate stimulation, confirmed by a subsequent spectral entropy analysis. Finally, time–frequency analyses of post-stimulation EEG, using image-based feature extraction, revealed no distinctions between effects of individual cues. Despite variability in acoustic properties, the evoked SOs remained spectrally similar, indicating similar early processing brain responses across different stimuli and suggesting that using a higher stimuli number may not be optimal for CL-TMR experiments.

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长时间听觉刺激对慢波睡眠中慢振荡的时间和地形影响

闭环定向记忆再激活（CL-TMR）是一种精确定位和再激活在睡眠中巩固的选择性记忆的新方法。电生理学上，慢振荡（SOs）被唤起，与非快速眼动（NREM） 3睡眠深度的增加有关。对300 ms声音刺激下NREM 3期睡眠数据进行诱发反应电位（ERP）分析。利用地形测绘和Hjorth参数进一步对so进行了表征，并根据增产阶段将试验分为上州和下州。我们的研究结果显示自发性和诱发性SOs在地形分布和信号复杂性方面存在显著差异。上状态刺激在额叶和枕叶区域产生了更强的反应，特别是在P300部分附近，这表明比下状态刺激有更大的认知加工，随后的谱熵分析证实了这一点。最后，使用基于图像的特征提取对刺激后脑电图进行时频分析，发现单个线索的影响之间没有差异。尽管声学特性存在差异，但诱发的SOs在频谱上仍然相似，这表明不同刺激下的早期处理大脑反应相似，并表明使用较高的刺激数量可能不是CL-TMR实验的最佳选择。

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来源期刊

Biomedical Signal Processing and Control 工程技术-工程：生物医学

CiteScore

9.80

自引率

13.70%

发文量

822

审稿时长

4 months

期刊介绍： Biomedical Signal Processing and Control aims to provide a cross-disciplinary international forum for the interchange of information on research in the measurement and analysis of signals and images in clinical medicine and the biological sciences. Emphasis is placed on contributions dealing with the practical, applications-led research on the use of methods and devices in clinical diagnosis, patient monitoring and management. Biomedical Signal Processing and Control reflects the main areas in which these methods are being used and developed at the interface of both engineering and clinical science. The scope of the journal is defined to include relevant review papers, technical notes, short communications and letters. Tutorial papers and special issues will also be published.