Codonopsis pilosula peptides/cellulose nanocrystals hydrogels: Preparation, characterization, and antibacterial/antioxidant properties

IF 4.7 3区材料科学 Q2 MATERIALS SCIENCE, MULTIDISCIPLINARY

Materials Chemistry and Physics Pub Date : 2025-09-11 DOI:10.1016/j.matchemphys.2025.131542

Fangyu Li, Yutao Wang, Wei Wei, Jia Zhou, Zhongbiao Tan, Hao Shi

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Abstract

Hydrogels have gained significant attention in biomedical applications due to their unique physicochemical properties. This study reports the fabrication of a composite hydrogel combining Codonopsis pilosula peptides (CPP) and cellulose nanocrystals (CNC), followed by a systematic evaluation of its properties. Fourier-transform infrared spectroscopy, scanning electron microscopy, and X-ray diffraction confirm effective crosslinking between CPP and CNC. The CPP/CNC hydrogel exhibits exceptional mechanical performance, with a break elongation of 2332 % and tensile strength of 442 kPa. It showed a high swelling ratio of 1011.58 % in phosphate-buffered saline (PBS, pH 7.4). Additionally, the hydrogel demonstrates remarkable antibacterial activity and free radical scavenging capacity, with the latter exceeding 95 %. These findings provide a theoretical and practical basis for the potential biomedical applications of CPP/CNC composite hydrogels, particularly in wound healing and drug delivery.

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党参肽/纤维素纳米晶体水凝胶：制备、表征和抗菌/抗氧化性能

水凝胶由于其独特的物理化学性质，在生物医学应用中受到了极大的关注。本研究报道了党参肽（CPP）和纤维素纳米晶体（CNC）复合水凝胶的制备，并对其性能进行了系统的评价。傅里叶变换红外光谱、扫描电镜和x射线衍射证实了CPP和CNC之间的有效交联。CPP/CNC水凝胶具有优异的力学性能，断裂伸长率为2332%，抗拉强度为442 kPa。在磷酸盐缓冲盐水（PBS, pH 7.4）中，肿胀率高达1011.58%。此外，水凝胶具有显著的抗菌活性和自由基清除能力，后者超过95%。这些发现为CPP/CNC复合水凝胶的潜在生物医学应用提供了理论和实践基础，特别是在伤口愈合和药物输送方面。

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来源期刊

Materials Chemistry and Physics 工程技术-材料科学：综合

CiteScore

8.70

自引率

4.30%

发文量

1515

审稿时长

69 days

期刊介绍： Materials Chemistry and Physics is devoted to short communications, full-length research papers and feature articles on interrelationships among structure, properties, processing and performance of materials. The Editors welcome manuscripts on thin films, surface and interface science, materials degradation and reliability, metallurgy, semiconductors and optoelectronic materials, fine ceramics, magnetics, superconductors, specialty polymers, nano-materials and composite materials.