Influence of the molar mass of PEGs on the miscibility of paracetamol: Study of binary phase diagrams. Application for FDM 3D printing

IF 2.7 3区工程技术 Q3 CHEMISTRY, PHYSICAL

Fluid Phase Equilibria Pub Date : 2025-09-08 DOI:10.1016/j.fluid.2025.114588

Veronica Ianno’, Philippe Espeau

引用次数: 0

Abstract

PEGs are often used as plasticizers in filaments formulated for FDM 3D printing. Here, we present the behavior of paracetamol in solid dispersions based on PEG 4000 and 6000 via the determination of binary phase diagrams. It is shown, as was already the case with PEG 1500, that paracetamol is present, almost obviously, in its polymorphic Form II during the second heating. This metastable form remains stable in the presence of PEG, and its solubility appears to be independent of the molar mass of PEG, as is the case for Form I. This work aims to mimic the behavior of paracetamol in the presence of PEG during an extrusion process by HME then coupled with 3D printing by FDM.

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聚乙二醇摩尔质量对扑热息痛混相的影响：二元相图的研究。FDM 3D打印应用

聚乙二醇通常用作FDM 3D打印的长丝中的增塑剂。在这里，我们提出了对乙酰氨基酚在固体分散基于peg4000和6000二元相图的测定行为。这表明，就像peg1500的情况一样，在第二次加热期间，扑热息痛几乎明显地以其多态形式II存在。这种亚稳态形式在PEG存在下保持稳定，其溶解度似乎与PEG的摩尔质量无关，就像形式i的情况一样。这项工作的目的是在HME挤压过程中模拟扑热息痛在PEG存在下的行为，然后通过FDM进行3D打印。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Fluid Phase Equilibria 工程技术-工程：化工

CiteScore

5.30

自引率

15.40%

发文量

223

审稿时长

53 days

期刊介绍： Fluid Phase Equilibria publishes high-quality papers dealing with experimental, theoretical, and applied research related to equilibrium and transport properties of fluids, solids, and interfaces. Subjects of interest include physical/phase and chemical equilibria; equilibrium and nonequilibrium thermophysical properties; fundamental thermodynamic relations; and stability. The systems central to the journal include pure substances and mixtures of organic and inorganic materials, including polymers, biochemicals, and surfactants with sufficient characterization of composition and purity for the results to be reproduced. Alloys are of interest only when thermodynamic studies are included, purely material studies will not be considered. In all cases, authors are expected to provide physical or chemical interpretations of the results. Experimental research can include measurements under all conditions of temperature, pressure, and composition, including critical and supercritical. Measurements are to be associated with systems and conditions of fundamental or applied interest, and may not be only a collection of routine data, such as physical property or solubility measurements at limited pressures and temperatures close to ambient, or surfactant studies focussed strictly on micellisation or micelle structure. Papers reporting common data must be accompanied by new physical insights and/or contemporary or new theory or techniques.