An Efficient Protocol for the Synthesis of Amcinonide from Tetraene Acetate

Abstract

Facile synthetic protocol has been designed for the topical corticosteroid Amcinonide. Topical corticosteroids are a group of mainly synthetic steroids utilized as anti-inflammatory and antipruritic agents. Amcinonide works by diminishing or blocking the actions of certain chemicals in the body that lead to inflammation, redness, and swelling. Current synthesis methods for Amcinonide are often complex and utilize hazardous materials. The innovative approach designed for synthesizing Amcinonide from tetraene acetate (3TR) involves three steps: oxidation, one-pot ketal-epoxide formation via bromohydrin, and fluorination. Present protocol offers several important benefits, including ease of operation, improved atom economy, reduced reaction time, and the incorporation of in-situ reaction.