Evaluation of Bisphenol A Levels in Children With Unprovoked Seizures

IF 2.1 3区医学 Q2 CLINICAL NEUROLOGY

Pediatric neurology Pub Date : 2025-08-27 DOI:10.1016/j.pediatrneurol.2025.08.014

Elif Perihan Oncel MD , Nihal Olgaç Dundar MD , Pınar Gençpınar MD , Pınar Arıcan MD , Seher Jabbari Behrouz MD , Fatma Demet Arslan MD , Bumin Nuri Dundar MD

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引用次数: 0

Abstract

Background

Bisphenol A (BPA) is a widely used chemical in plastics and epoxy resins, with potential neurotoxic effects. Limited evidence links BPA exposure to seizures, yet the mechanisms remain unclear.

Objective

This study aimed to investigate the relationship between urinary BPA levels and unprovoked seizures in children.

Methods

Urine samples from children presenting with seizures and age-matched healthy control subjects were analyzed for BPA levels. BPA/body surface area (BSA) ratios and creatinine-indexed BPA levels were calculated. Statistical comparisons were made to assess associations between BPA exposure and seizure incidence.

Results

The mean urinary BPA levels were significantly higher in the control group (0.067 ± 0.057 μg/mL) compared with the patient group (0.029 ± 0.322 μg/mL; P = 0.024). No significant differences were observed between the groups for BPA/BSA ratios (P = 0.463) or creatinine-indexed BPA levels (P = 0.452). Although higher BPA levels were noted in younger children, no significant association was found between BPA levels and seizure type or recurrence.

Conclusions

The study highlights discrepancies in BPA measurement methods and suggests age and body composition as critical factors influencing BPA levels. Although no direct link between BPA and seizures was established, the results underscore the importance of standardized methods for BPA assessment and the need for larger studies to explore potential neurotoxic effects.

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非诱发性癫痫患儿双酚A水平的评价

双酚A （BPA）是一种广泛应用于塑料和环氧树脂中的化学物质，具有潜在的神经毒性作用。有限的证据表明BPA暴露与癫痫发作有关，但机制尚不清楚。目的探讨儿童尿中BPA水平与非诱发性癫痫发作的关系。方法对癫痫发作儿童和年龄匹配的健康对照者的尿液样本进行双酚a水平分析。计算BPA/体表面积（BSA）比率和肌酐指数BPA水平。通过统计比较来评估BPA暴露与癫痫发作之间的关系。结果对照组尿BPA均值（0.067±0.057 μg/mL）显著高于患者组（0.029±0.322 μg/mL, P = 0.024）。BPA/BSA比值（P = 0.463）和肌酸酐指数BPA水平（P = 0.452）组间无显著差异。虽然在年幼的儿童中发现了较高的双酚a水平，但在双酚a水平与癫痫发作类型或复发之间没有发现显著的联系。结论该研究强调了BPA测量方法的差异，并提示年龄和身体成分是影响BPA水平的关键因素。虽然BPA和癫痫发作之间没有直接联系，但研究结果强调了标准化BPA评估方法的重要性，以及对潜在神经毒性效应进行更大规模研究的必要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pediatric neurology 医学-临床神经学

CiteScore

4.80

自引率

2.60%

发文量

176

审稿时长

78 days

期刊介绍： Pediatric Neurology publishes timely peer-reviewed clinical and research articles covering all aspects of the developing nervous system. Pediatric Neurology features up-to-the-minute publication of the latest advances in the diagnosis, management, and treatment of pediatric neurologic disorders. The journal''s editor, E. Steve Roach, in conjunction with the team of Associate Editors, heads an internationally recognized editorial board, ensuring the most authoritative and extensive coverage of the field. Among the topics covered are: epilepsy, mitochondrial diseases, congenital malformations, chromosomopathies, peripheral neuropathies, perinatal and childhood stroke, cerebral palsy, as well as other diseases affecting the developing nervous system.