Aberrant Nutrient Metabolism in T Cells: Pathogenesis Insight and Therapeutic Target for Autoimmune Diseases

IF 3.7 3区 医学 Q2 IMMUNOLOGY
Shumei Cao, Jiao Jiang, Haoyuan Yin, Xiaoyu Su, Qilin Li, Junhui Wu, Wenrui Li, Lai Wang, Qianjin Lu
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Abstract

Abnormal T-cell activation and differentiation are pivotal in the pathogenesis of autoimmune disorders. Traditionally, T cell activation is orchestrated by three canonical signals: antigen recognition through the T-cell receptor (TCR) and major histocompatibility complex (MHC) interaction, co-stimulatory signals, and cytokine signaling. Recent studies have highlighted nutrients as a key fourth signal in modulating T cell immunity. T cell metabolism is integral to regulating cell proliferation, survival, and differentiation. Dysregulation of nutrient metabolism, including glucose, amino acids, and lipids, has been considered a crucial determinant of T cell activation, differentiation, and function, and may lead to the disease progression of autoimmune disorders, including systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), and multiple sclerosis (MS). This review aims to elucidate the impact of T cell metabolic reprogramming on autoimmune disease development and explore potential therapeutic approaches targeting nutrient metabolism for treating autoimmune disorders.

Abstract Image

T细胞异常营养代谢:自身免疫性疾病的发病机制和治疗靶点
异常t细胞活化和分化在自身免疫性疾病的发病机制中起关键作用。传统上,T细胞活化是由三种典型信号协调的:通过T细胞受体(TCR)和主要组织相容性复合体(MHC)相互作用的抗原识别,共刺激信号和细胞因子信号。最近的研究强调,营养物质是调节T细胞免疫的第四个关键信号。T细胞代谢是调节细胞增殖、存活和分化的必要条件。营养代谢的失调,包括葡萄糖、氨基酸和脂质,被认为是T细胞活化、分化和功能的关键决定因素,并可能导致自身免疫性疾病的疾病进展,包括系统性红斑狼疮(SLE)、类风湿性关节炎(RA)和多发性硬化症(MS)。本文旨在阐明T细胞代谢重编程对自身免疫性疾病发展的影响,并探索以营养代谢为靶点治疗自身免疫性疾病的潜在治疗方法。
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来源期刊
CiteScore
8.30
自引率
3.70%
发文量
224
审稿时长
2 months
期刊介绍: The European Journal of Immunology (EJI) is an official journal of EFIS. Established in 1971, EJI continues to serve the needs of the global immunology community covering basic, translational and clinical research, ranging from adaptive and innate immunity through to vaccines and immunotherapy, cancer, autoimmunity, allergy and more. Mechanistic insights and thought-provoking immunological findings are of interest, as are studies using the latest omics technologies. We offer fast track review for competitive situations, including recently scooped papers, format free submission, transparent and fair peer review and more as detailed in our policies.
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