Methylsulfonylmethane Mitigates Neurobehavioral Impairment, Oxidative Stress, Changes in Trace Elements and Clock Expression in Alcohol and Circadian-Disrupted C57BL/6J Mice Brain

IF 3.8 3区 医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY
Indrani Paramasivan Latha Laxmi, Ramasamy Tamizhselvi
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引用次数: 0

Abstract

Alcohol consumption can affect the brain due to an elevation in oxidative stress and inflammation. Alcoholism influences the brain homeostasis and is often associated with cognitive, emotional and behavioral changes. Excessive alcohol intake can lead to poor sleep quality, and individuals with alcohol use disorder generally develop insomnia. Alcohol use affects the expression of clock genes, altering the physiological and immune function regulated by the biological clock, and hence elevating the production of reactive oxygen species. This study aimed to explore the alterations in neurobehavioral function associated with circadian disturbance and alcohol exposure, and to understand the potential therapeutic effect of methylsulfonylmethane on alcohol-administered and circadian-disrupted C57BL/6J mice. The sleep cycle of the mice was disturbed by 10 h light/10 h dark exposure, and 25% w/v alcohol was administered to the mice intragastrically. The concentration of trace elements in the mouse brain was measured using Inductively Coupled Mass Spectrometry (ICP-MS). An increase in anxiety-like behavior was observed in the mice exposed to alcohol and the circadian-disrupted groups. The administration of the drug significantly increased the expression of core clock genes in the alcohol and circadian-disrupted group. The levels of calcium and iron were increased in the MSM-administered mice, reversing the effects of circadian disruption and the alcohol-exposed group of mice. Our findings suggest that alcohol and circadian disturbance impact neurological function through alterations in immune homeostasis. MSM treatment can improve the expression of clock genes in alcohol and circadian-disrupted conditions, highlighting its neuroprotective potential by reducing inflammation.

甲基磺酰甲烷减轻酒精和昼夜节律紊乱的C57BL/6J小鼠大脑中神经行为损伤、氧化应激、微量元素和时钟表达的变化
由于氧化应激和炎症的升高,饮酒会影响大脑。酒精中毒影响大脑的内稳态,通常与认知、情绪和行为的改变有关。过量饮酒会导致睡眠质量差,有酒精使用障碍的人通常会患上失眠。饮酒影响生物钟基因的表达,改变生物钟调节的生理和免疫功能,从而提高活性氧的产生。本研究旨在探讨与昼夜节律紊乱和酒精暴露相关的神经行为功能改变,并了解甲基磺酰甲烷对酒精给药和昼夜节律紊乱的C57BL/6J小鼠的潜在治疗作用。10 h光照/10 h黑暗暴露干扰小鼠睡眠周期,小鼠灌胃25% w/v酒精。采用电感耦合质谱法(ICP-MS)测定小鼠脑内微量元素浓度。在暴露于酒精和昼夜节律紊乱组的小鼠中,观察到焦虑样行为的增加。在酒精和昼夜节律紊乱组中,给药显著增加了核心时钟基因的表达。服用msm的小鼠体内的钙和铁含量增加,逆转了昼夜节律紊乱和酒精暴露组小鼠的影响。我们的研究结果表明,酒精和昼夜节律紊乱通过改变免疫稳态影响神经功能。男同性恋者治疗可以改善酒精和昼夜节律紊乱情况下生物钟基因的表达,通过减少炎症突出其神经保护潜力。
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来源期刊
Neurochemical Research
Neurochemical Research 医学-神经科学
CiteScore
7.70
自引率
2.30%
发文量
320
审稿时长
6 months
期刊介绍: Neurochemical Research is devoted to the rapid publication of studies that use neurochemical methodology in research on nervous system structure and function. The journal publishes original reports of experimental and clinical research results, perceptive reviews of significant problem areas in the neurosciences, brief comments of a methodological or interpretive nature, and research summaries conducted by leading scientists whose works are not readily available in English.
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