Insights into the Expression, Structure, and Function of the Thromboxane A2 Receptor in Vascular Biology

IF 3.7 Q1 CHEMISTRY, MEDICINAL

ACS Pharmacology and Translational Science Pub Date : 2025-08-10 DOI:10.1021/acsptsci.5c00378

Robert Eckenstaler, and , Ralf A. Benndorf*,

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引用次数: 0

Abstract

The thromboxane A₂ receptor is known for its role in platelet aggregation. In platelets, loss or gain-of-function of the thromboxane A₂ receptor may therefore lead to bleeding disorders or prothrombotic conditions. However, the thromboxane A₂ receptor is also expressed in many other cell types and tissues and is thought to contribute to a broad range of other pathophysiological processes, such as pulmonary hypertension and cancer cell metastasis. In endothelial cells, the thromboxane A₂ receptor is an important player in the pathogenesis of endothelial dysfunction, one of the main contributors to the development of hypertension and atherosclerosis-related diseases. In this review, we provide insight into the genomic structure and expression, protein structure and function of the thromboxane A₂ receptor, with a particular focus on vascular (patho)physiology and recent findings regarding the involvement of thromboxane A₂ receptor signaling in the pathogenesis of endothelial dysfunction and cardiovascular disease. In addition, we provide an overview of clinically relevant polymorphisms within the thromboxane A₂ receptor gene (TBXA2R) and their influence on gene expression, protein structure, and receptor pathophysiology.

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血管生物学中血栓素A2受体的表达、结构和功能的研究

血栓素A2受体因其在血小板聚集中的作用而闻名。在血小板中，血栓素A2受体功能的丧失或获得可能导致出血性疾病或血栓前病变。然而，血栓素A2受体也在许多其他细胞类型和组织中表达，并被认为有助于广泛的其他病理生理过程，如肺动脉高压和癌细胞转移。在内皮细胞中，血栓素A2受体在内皮功能障碍的发病机制中起着重要作用，是高血压和动脉粥样硬化相关疾病发生的主要因素之一。在这篇综述中，我们提供了对血栓素A2受体的基因组结构和表达、蛋白质结构和功能的深入研究，特别关注血管（病理）生理学和关于血栓素A2受体信号在内皮功能障碍和心血管疾病发病机制中的参与的最新发现。此外，我们还概述了血栓素A2受体基因（TBXA2R）的临床相关多态性及其对基因表达、蛋白质结构和受体病理生理的影响。

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来源期刊

ACS Pharmacology and Translational Science Medicine-Pharmacology (medical)

CiteScore

10.00

自引率

3.30%

发文量

133

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