Elizabeth R Flammer, Michael W Christopher, Esabella R Powers, Hali Broncucia, Andrea K Steck, Stephen E Gitelman, Timothy J Garrett, Heba M Ismail
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Abstract
Article highlights: We believed this cohort of twins discordant for type 1 diabetes (T1D) would allow for control over genetic variability to examine environmental factors. We aimed to identify differences in microbial and microbiota-associated metabolites in twins discordant for T1D to examine the effect of the gut microbiome on T1D. Thirteen metabolites were identified as significantly different. Our results show dysregulation of several microbial metabolites in twin pairs, suggesting the role of the gut microbiome in T1D pathogenesis.
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