EFFECT OF PHYSICAL EXERCISE ON THE HEALTH-RELATED QUALITY OF LIFE ASSESSED BY CLDQ OF LIVER CIRRHOSIS PATIENTS: SYSTEMATIC REVIEW WITH META-ANALYSIS.

Q2 Medicine

Arquivos de Gastroenterologia Pub Date : 2025-09-05 eCollection Date: 2025-01-01 DOI:10.1590/S0004-2803.24612025-024

Fabiana Coelho Couto Rocha Corrêa, Isabella Scarlatelli Telles Pires Nader, Laura Candeia Barbosa Muniz, Roberta Martins Lopes, Elirez Bezerra da Silva

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Abstract

Objective: To verify the effect of physical exercise on the quality of life of patients with liver cirrhosis (LC).

Methods: the sample included controlled and randomized experimental studies of individuals with LC, at any stage of the disease, over 18 years of age, of both sexes, who performed any type of physical exercise compared to any other intervention or no intervention, with quality of life as the outcome assessed by the Chronic Liver Disease Questionnaire (CLDQ). The search for articles was conducted in 11 databases. The descriptors considered for the search were physical exercise, quality of life, liver cirrhosis, and their synonyms. The methodological quality and study bias were assessed using the Jadad scale and the RoB 2 scale, respectively. Review Manager 5.4 was used for the meta-analysis of the data. Quality of life was considered a continuous variable. The mean difference was considered as the effect measure. The analysis model was fixed-effect. The confidence level adopted was .05. The level of evidence for the meta-analysis results was assessed using the GRADE tool.

Results: A meta-analysis of five studies, in which 153 participants with LC, of which 83 belonged to the physical exercise group and 70 to the control group, showed that the experimental group that performed physical exercise significantly increased quality of life by 0.46 [0.09 to 0.84]; P=.02. The level of evidence of the meta-analysis was considered high.

Conclusion: Physical exercise led to an improvement in the health-related quality of life of patients with LC.

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体育锻炼对肝硬化患者CLDQ评估的健康相关生活质量的影响：系统评价与meta分析

目的：探讨体育锻炼对肝硬化（LC）患者生活质量的影响。方法：样本包括对照和随机实验研究的LC个体，在疾病的任何阶段，18岁以上，男女，进行任何类型的体育锻炼，与任何其他干预或不干预相比，生活质量作为慢性肝病问卷（CLDQ）评估的结果。文章检索在11个数据库中进行。研究中考虑的描述词包括体育锻炼、生活质量、肝硬化及其同义词。分别采用Jadad量表和RoB 2量表评估方法学质量和研究偏倚。使用Review Manager 5.4对数据进行meta分析。生活质量被认为是一个连续的变量。将平均差值作为效果度量。分析模型为固定效应。采用的置信水平为0.05。使用GRADE工具评估meta分析结果的证据水平。结果：对153名LC参与者的5项研究进行meta分析，其中体育锻炼组83人，对照组70人，结果显示，进行体育锻炼的实验组生活质量显著提高0.46 [0.09 ~ 0.84]；P = .02点。荟萃分析的证据水平被认为是高的。结论：体育锻炼可改善LC患者的健康相关生活质量。

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来源期刊

Arquivos de Gastroenterologia Medicine-Gastroenterology

CiteScore

2.00

自引率

0.00%

发文量

109

审稿时长

9 weeks

期刊介绍： The journal Arquivos de Gastroenterologia (Archives of Gastroenterology), a quarterly journal, is the Official Publication of the Instituto Brasileiro de Estudos e Pesquisas de Gastroenterologia IBEPEGE (Brazilian Institute for Studies and Research in Gastroenterology), Colégio Brasileiro de Cirurgia Digestiva - CBCD (Brazilian College of Digestive Surgery) and of the Sociedade Brasileira de Motilidade Digestiva - SBMD (Brazilian Digestive Motility Society). It is dedicated to the publishing of scientific papers by national and foreign researchers who are in agreement with the aim of the journal as well as with its editorial policies.