SELF-REPORTED QUALITY OF LIFE, IMPULSIVITY AND NON-ADHERENCE TO IMMUNOSUPPRESSIVE MEDICATION AFTER LIVER TRANSPLANTATION: A COHORT STUDY.

Q2 Medicine

Arquivos de Gastroenterologia Pub Date : 2025-09-05 eCollection Date: 2025-01-01 DOI:10.1590/S0004-2803.24612025-012

Ana Paula Jesus-Nunes, Tayne M Moreira, Mychelle Morais-DE-Jesus, Raymundo Paraná, Liliane Lins-Kusterer, Lucas C Quarantini

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引用次数: 0

Abstract

Objective: Identify psychosocial risk factors for non-adherence to medication following liver transplantation.

Methods: We used the Medication Level Variability Index (MLVI) for the assessment of adherence in 52 subjects selected for a pre-transplant liver procedure and monitored them for 6 months following transplantation. Patients were divided into exposed and non-exposed groups according to adherence, and each group was analyzed using psychosocial variables: demographic characteristics, quality of life, impulsivity, resilience, anxiety and depression.

Results: Patients with non-adherence had lower scores in the SF-36v2 domains and in the components of physical and mental health, with significant differences in the physical functioning (P=0.03) and physical health component (P=0.03) domains. In addition, non-adherent patients showed higher levels of impulsiveness (P=0.04) and 44.2% of the non-adherent patients being men (P=0.04).

Conclusion: Physical functioning and summary of the physical components of quality of life, impulsivity and male gender were associated with low adherence to medication.

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肝移植后自我报告的生活质量、冲动性和免疫抑制药物不依从性：一项队列研究

目的：确定肝移植术后不遵医嘱的社会心理危险因素。方法：我们使用药物水平变异性指数（MLVI）评估52名接受肝移植前手术的受试者的依从性，并在移植后监测他们6个月。根据依从性将患者分为暴露组和未暴露组，并使用社会心理变量对每组进行分析：人口统计学特征、生活质量、冲动性、恢复力、焦虑和抑郁。结果：不依从性患者在SF-36v2域和身心健康分项得分较低，在身体功能（P=0.03）和身体健康分项得分（P=0.03）差异有统计学意义。此外，非依从性患者冲动水平较高（P=0.04）， 44.2%的非依从性患者为男性（P=0.04）。结论：身体功能、生活质量、冲动性和男性与药物依从性低有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Arquivos de Gastroenterologia Medicine-Gastroenterology

CiteScore

2.00

自引率

0.00%

发文量

109

审稿时长

9 weeks

期刊介绍： The journal Arquivos de Gastroenterologia (Archives of Gastroenterology), a quarterly journal, is the Official Publication of the Instituto Brasileiro de Estudos e Pesquisas de Gastroenterologia IBEPEGE (Brazilian Institute for Studies and Research in Gastroenterology), Colégio Brasileiro de Cirurgia Digestiva - CBCD (Brazilian College of Digestive Surgery) and of the Sociedade Brasileira de Motilidade Digestiva - SBMD (Brazilian Digestive Motility Society). It is dedicated to the publishing of scientific papers by national and foreign researchers who are in agreement with the aim of the journal as well as with its editorial policies.