Effect of Total Psoas Muscle Area and Serum Albumin on Outcomes After Lung Transplantation

IF 1.9 4区医学 Q2 SURGERY

Clinical Transplantation Pub Date : 2025-09-11 DOI:10.1111/ctr.70308

Domingo J. Franco-Palacios, Carlos R. Franco-Palacios, Sarah Crowley, Lisa L. Allenspach, Lisa Stagner, Julio Pinto Corrales, Kaitlin Olexsey, Lisa Waynick, Jane Simanovski, Humza Bhatti, Ryann Laier, Adele Myszenski, Yichu Wang, Mei Lu, Thomas Song

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引用次数: 0

Abstract

Background

Sarcopenia of the psoas muscle and hypoalbuminemia indicate poor nutritional status, inflammation, and frailty in lung transplant (LT) candidates, correlating with worse post-transplant outcomes.

Methods

Retrospective study of LT recipients (2015–2023) examining the association of total psoas muscle area (TPA) and serum albumin with hospital stay, survival, and pulmonary function.

Results

One hundred thirty-two LT recipients (mean age 59.56 ± 10.65 years, BMI 26.73 ± 5.55 kg/m², 65% males), 95% underwent bilateral LT. Higher TPA was associated with shorter hospital and ICU stays (p = 0.001). Similarly, higher albumin levels were associated with reduced hospital and ICU stays (p < 0.001). Hospital survivors had higher TPA (17.5 ± 6.1 vs. 14.6 ± 5.2 cm², p = 0.02) and higher albumin levels (3.25 ± 0.73 vs. 2.75 ± 0.85 mg/dL, p = 0.01). Long-term survivors had higher TPA (17.8 ± 6.35 vs. 15.9 ± 5.51 cm², p = 0.07) and higher albumin levels (3.29 ± 0.75 vs. 2.97 ± 0.78 mg/dL, p = 0.01). On multivariate analysis, albumin and male gender remained independent predictors of hospital and long-term survival. TPA was positively associated with post-transplant pulmonary function based on FVC and FEV1 (p < 0.001), while albumin levels showed no association.

Conclusion

In the present study of LT recipients, higher TPA and albumin levels were linked to shorter hospitalization, and albumin independently predicted survival. TPA, but not albumin, was associated with pulmonary function post-transplant.

Abstract Image

查看原文本刊更多论文

腰肌总面积和血清白蛋白对肺移植术后预后的影响。

背景：腰肌肌肉减少症和低白蛋白血症表明肺移植（LT）候选人营养状况不佳、炎症和虚弱，与较差的移植后预后相关。方法：回顾性研究2015-2023年肝移植患者腰大肌总面积（TPA）和血清白蛋白与住院时间、生存率和肺功能的关系。结果：132例肝移植患者（平均年龄59.56±10.65岁，BMI 26.73±5.55 kg/m2, 65%男性），95%接受双侧肝移植。TPA越高，住院和ICU时间越短（p = 0.001）。同样，较高的白蛋白水平与住院和ICU住院时间缩短（p 2, p = 0.02）和较高的白蛋白水平（3.25±0.73 vs. 2.75±0.85 mg/dL, p = 0.01）相关。长期存活者TPA较高（17.8±6.35 vs 15.9±5.51 cm2, p = 0.07），白蛋白水平较高（3.29±0.75 vs 2.97±0.78 mg/dL, p = 0.01）。在多变量分析中，白蛋白和男性性别仍然是医院和长期生存的独立预测因素。基于FVC和FEV1的TPA与移植后肺功能呈正相关(p结论：在本研究中，较高的TPA和白蛋白水平与较短的住院时间有关，白蛋白独立预测生存。TPA与移植后肺功能相关，而白蛋白与肺功能无关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Transplantation 医学-外科

CiteScore

3.70

自引率

4.80%

发文量

286

审稿时长

2 months

期刊介绍： Clinical Transplantation: The Journal of Clinical and Translational Research aims to serve as a channel of rapid communication for all those involved in the care of patients who require, or have had, organ or tissue transplants, including: kidney, intestine, liver, pancreas, islets, heart, heart valves, lung, bone marrow, cornea, skin, bone, and cartilage, viable or stored. Published monthly, Clinical Transplantation’s scope is focused on the complete spectrum of present transplant therapies, as well as also those that are experimental or may become possible in future. Topics include: Immunology and immunosuppression; Patient preparation; Social, ethical, and psychological issues; Complications, short- and long-term results; Artificial organs; Donation and preservation of organ and tissue; Translational studies; Advances in tissue typing; Updates on transplant pathology;. Clinical and translational studies are particularly welcome, as well as focused reviews. Full-length papers and short communications are invited. Clinical reviews are encouraged, as well as seminal papers in basic science which might lead to immediate clinical application. Prominence is regularly given to the results of cooperative surveys conducted by the organ and tissue transplant registries. Clinical Transplantation: The Journal of Clinical and Translational Research is essential reading for clinicians and researchers in the diverse field of transplantation: surgeons; clinical immunologists; cryobiologists; hematologists; gastroenterologists; hepatologists; pulmonologists; nephrologists; cardiologists; and endocrinologists. It will also be of interest to sociologists, psychologists, research workers, and to all health professionals whose combined efforts will improve the prognosis of transplant recipients.