Protein intake counteracts alcohol intake in the regulation of postprandial FGF21 secretion in humans.

IF 3.1 2区 医学 Q1 ENDOCRINOLOGY & METABOLISM
Stina Ramne, Teresa Duarte da Costa Seco, Katharina B Kuentzel, Trisha J Grevengoed, Jasmin P Hjerresen, Thomas Moritz, Torben Hansen, Anne Raben, Niels Grarup
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引用次数: 0

Abstract

FGF21 is a hormone secreted from the liver in response to various nutritional stressors, suggested to be acting to balance dietary intake through negative feedback regulation. This meal study aimed to investigate two different potential nutrient interactions on postprandial FGF21 secretion in healthy human participants: 1) between intake of alcohol and protein and 2) between intake of alcohol and vitamin A (retinol). In a 4-arm, randomized, double-blinded, cross-over meal study (NCT06105476), postprandial circulating concentrations of FGF21, glucose, insulin, ethanol, and acetate were compared after intake of four different test drinks containing alcohol, alcohol+protein, alcohol+retinol or retinol in 27 healthy humans. The postprandial FGF21 response to the alcohol+protein drink was severely attenuated compared to the alcohol drink. The FGF21 response to the alcohol+retinol drink was similar to the alcohol drink, while there was no FGF21 response to the drink with retinol only. In conclusion, intake of protein inhibited the secretory FGF21 response to alcohol intake, while retinol intake did not appear to influence FGF21 secretion.

蛋白质摄入抵消酒精摄入对人类餐后FGF21分泌的调节。
FGF21是一种由肝脏分泌的激素,是对各种营养压力源的反应,被认为是通过负反馈调节来平衡饮食摄入。这项膳食研究旨在研究健康人类参与者餐后FGF21分泌的两种不同的潜在营养相互作用:1)摄入酒精和蛋白质之间的相互作用,以及2)摄入酒精和维生素A(视黄醇)之间的相互作用。在一项四组、随机、双盲、跨餐研究(NCT06105476)中,对27名健康人在摄入含酒精、酒精+蛋白质、酒精+视黄醇或视黄醇的四种不同测试饮料后,餐后循环中FGF21、葡萄糖、胰岛素、乙醇和醋酸盐的浓度进行了比较。餐后FGF21对酒精+蛋白质饮料的反应与酒精饮料相比严重减弱。FGF21对酒精+视黄醇饮料的反应与酒精饮料相似,而对只含视黄醇的饮料没有FGF21反应。综上所述,摄入蛋白质抑制FGF21分泌对酒精的反应,而摄入视黄醇似乎不影响FGF21分泌。
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来源期刊
CiteScore
9.80
自引率
0.00%
发文量
98
审稿时长
1 months
期刊介绍: The American Journal of Physiology-Endocrinology and Metabolism publishes original, mechanistic studies on the physiology of endocrine and metabolic systems. Physiological, cellular, and molecular studies in whole animals or humans will be considered. Specific themes include, but are not limited to, mechanisms of hormone and growth factor action; hormonal and nutritional regulation of metabolism, inflammation, microbiome and energy balance; integrative organ cross talk; paracrine and autocrine control of endocrine cells; function and activation of hormone receptors; endocrine or metabolic control of channels, transporters, and membrane function; temporal analysis of hormone secretion and metabolism; and mathematical/kinetic modeling of metabolism. Novel molecular, immunological, or biophysical studies of hormone action are also welcome.
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