Biological Sex and Cardiovascular Disease Prevention in Systemic Arterial Hypertension.

IF 7.4 1区医学 Q1 HEMATOLOGY

Arteriosclerosis, Thrombosis, and Vascular Biology Pub Date : 2025-09-11 DOI:10.1161/ATVBAHA.125.322092

Eva Gerdts, Susana Novella, Yvan Devaux, Paolo Magni, Hans Peter Marti, Miron Sopić, Georgios Kararigas

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引用次数: 0

Abstract

Biological sex influences the life course development of blood pressure, systemic arterial hypertension, and hypertension-associated complications through neural, hormonal, renal, and epigenetic mechanisms. Sex hormones influence blood pressure regulation through interaction with several main regulatory systems, including the autonomic nervous system, the renin-angiotensin-aldosterone system, endothelin, and renal mechanisms. The modulation of vascular function by sex hormones varies over the lifespan. A more progressive decline in vascular endothelial function and an increase in vascular remodeling and arterial stiffness with aging are found in female individuals. Epigenetic mechanisms, including DNA methylation, histone modifications, and noncoding microRNAs, may be implicated in systemic arterial hypertension development and complications. Overall, current knowledge highlights the importance of including biological sex as a critical factor in understanding systemic arterial hypertension pathophysiology and advancing cardiovascular prevention.

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系统性动脉高血压的生理性别与心血管疾病预防。

生理性别通过神经、激素、肾脏和表观遗传机制影响血压、全身性动脉高血压和高血压相关并发症的生命历程发展。性激素通过与几个主要调节系统的相互作用来影响血压调节，包括自主神经系统、肾素-血管紧张素-醛固酮系统、内皮素和肾脏机制。性激素对血管功能的调节在人的一生中是不同的。在女性个体中，随着年龄的增长，血管内皮功能逐渐下降，血管重塑和动脉硬化增加。表观遗传机制，包括DNA甲基化、组蛋白修饰和非编码microrna，可能与全身性动脉高血压的发展和并发症有关。总的来说，目前的知识强调了将生理性别作为理解全身性动脉高血压病理生理和推进心血管预防的关键因素的重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Arteriosclerosis, Thrombosis, and Vascular Biology 医学-外周血管病

CiteScore

15.60

自引率

2.30%

发文量

337

审稿时长

2-4 weeks

期刊介绍： The journal "Arteriosclerosis, Thrombosis, and Vascular Biology" (ATVB) is a scientific publication that focuses on the fields of vascular biology, atherosclerosis, and thrombosis. It is a peer-reviewed journal that publishes original research articles, reviews, and other scholarly content related to these areas. The journal is published by the American Heart Association (AHA) and the American Stroke Association (ASA). The journal was published bi-monthly until January 1992, after which it transitioned to a monthly publication schedule. The journal is aimed at a professional audience, including academic cardiologists, vascular biologists, physiologists, pharmacologists and hematologists.