{"title":"Late-onset immune thrombocytopenia after unrelated cord blood transplantation for chronic myelomonocytic leukemia.","authors":"Shoya Arai, Kensuke Matsumoto, Haruko Tashiro, Seiko Kato, Takaaki Konuma, Jun Ooi","doi":"10.31547/bct-2025-004","DOIUrl":null,"url":null,"abstract":"<p><p>Several reports have been published on autoimmune hematologic complications, including immune thrombocytopenia (ITP), after cord blood transplantation (CBT). However, there have been no reports of late-onset ITP following CBT. A 51-year-old male with chronic myelomonocytic leukemia received unrelated CBT in 2012. During regular follow-up visits every 3-6 months, his complete blood count remained normal until March 2024. In September 2024, 12 years after the CBT, the patient suddenly developed severe thrombocytopenia. Following a diagnosis of ITP, the patient was treated with intravenous immunoglobulins and prednisone. With follow-up period of 5 months after the onset of ITP, the patient is still alive with a platelet count of 126 × 10<sup>9</sup>/L. This case suggests that late-onset ITP after CBT occurred suddenly and may be life-threatening. Long-term follow-ups and regular clinic visits may reduce the risk of delays in diagnosis and treatment.</p>","PeriodicalId":72423,"journal":{"name":"Blood cell therapy","volume":"8 3","pages":"225-227"},"PeriodicalIF":0.0000,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12414648/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Blood cell therapy","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.31547/bct-2025-004","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/8/25 0:00:00","PubModel":"eCollection","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Several reports have been published on autoimmune hematologic complications, including immune thrombocytopenia (ITP), after cord blood transplantation (CBT). However, there have been no reports of late-onset ITP following CBT. A 51-year-old male with chronic myelomonocytic leukemia received unrelated CBT in 2012. During regular follow-up visits every 3-6 months, his complete blood count remained normal until March 2024. In September 2024, 12 years after the CBT, the patient suddenly developed severe thrombocytopenia. Following a diagnosis of ITP, the patient was treated with intravenous immunoglobulins and prednisone. With follow-up period of 5 months after the onset of ITP, the patient is still alive with a platelet count of 126 × 109/L. This case suggests that late-onset ITP after CBT occurred suddenly and may be life-threatening. Long-term follow-ups and regular clinic visits may reduce the risk of delays in diagnosis and treatment.
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