[The Relationship of Markers of Cellular Aging with Atrial Fibrillation].

IF 0.5 4区医学 Q4 CARDIAC & CARDIOVASCULAR SYSTEMS

Kardiologiya Pub Date : 2025-09-10 DOI:10.18087/cardio.2025.8.n2914

O V Zimnitskaya, O M Drapkina

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引用次数: 0

Abstract

Atrial fibrillation (AF) is the most common form of cardiac arrhythmia, the prevalence of which increases with age. Slowing down senescence is one of the urgent challenges of modern science. Therefore, it is important to identify individuals with markers of premature cellular senescence for further development of pharmacological agents capable of slowing it. Assuming that in AF, signs of cellular senescence emerge earlier than in individuals without AF we performed search, analysis and systematization of studies of the relationship between markers of cellular senescence, including the leukocyte telomere length (LTL) and the plasma concentration of galectin-3 in patients with AF. In most of the reviewed studies, the concentration of galectin-3 was significantly higher in patients with AF than in practically healthy individuals, while the LTL did not differ significantly between these groups. Accordingly, the signs of cellular senescence appeared earlier in patients with AF than in practically healthy individuals. Further clinical studies of cellular senescence markers in patients with AF are promising and call for large multicenter studies with a uniform design and methodology.

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细胞老化标志物与房颤的关系

心房颤动（AF）是最常见的心律失常形式，其患病率随着年龄的增长而增加。延缓衰老是现代科学面临的紧迫挑战之一。因此，识别具有细胞过早衰老标记的个体对于进一步开发能够减缓衰老的药理学药物是很重要的。假设在房颤中，细胞衰老的迹象比没有房颤的个体更早出现，我们对房颤患者中细胞衰老标志物（包括白细胞端粒长度（LTL）和血浆半乳糖凝集素-3浓度）之间关系的研究进行了搜索、分析和系统化。在大多数回顾的研究中，房颤患者的半乳糖凝集素-3浓度明显高于实际健康个体。而LTL在两组间无显著差异。因此，房颤患者的细胞衰老迹象比实际健康个体出现得更早。房颤患者细胞衰老标志物的进一步临床研究是有希望的，需要统一设计和方法的大型多中心研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Kardiologiya 医学-心血管系统

CiteScore

1.70

自引率

20.00%

发文量

审稿时长

3-8 weeks

期刊介绍： “Kardiologiya” (Cardiology) is a monthly scientific, peer-reviewed journal committed to both basic cardiovascular medicine and practical aspects of cardiology. As the leader in its field, “Kardiologiya” provides original coverage of recent progress in cardiovascular medicine. We publish state-of-the-art articles integrating clinical and research activities in the fields of basic cardiovascular science and clinical cardiology, with a focus on emerging issues in cardiovascular disease. Our target audience spans a diversity of health care professionals and medical researchers working in cardiovascular medicine and related fields. The principal language of the Journal is Russian, an additional language – English (title, authors’ information, abstract, keywords). “Kardiologiya” is a peer-reviewed scientific journal. All articles are reviewed by scientists, who gained high international prestige in cardiovascular science and clinical cardiology. The Journal is currently cited and indexed in major Abstracting & Indexing databases: Web of Science, Medline and Scopus. The Journal''s primary objectives Contribute to raising the professional level of medical researchers, physicians and academic teachers. Present the results of current research and clinical observations, explore the effectiveness of drug and non-drug treatments of heart disease, inform about new diagnostic techniques; discuss current trends and new advancements in clinical cardiology, contribute to continuing medical education, inform readers about results of Russian and international scientific forums; Further improve the general quality of reviewing and editing of manuscripts submitted for publication; Provide the widest possible dissemination of the published articles, among the global scientific community; Extend distribution and indexing of scientific publications in major Abstracting & Indexing databases.