Liver Fibrosis and Quality of Life in Liver Transplant Recipients Over 10 Years: A Cross-Sectional Study Using Transient Elastography.

Abstract

Objectives: Liver transplant has significantly improved the survival of patients with end-stage liver disease, yet long-term transplant recipients often face challenges related to graft function and well-being. We aimed to evaluate the clinical role of vibration-controlled transi-ent elastography for assessment of liver fibrosis and steatosis, with a focus on fibrosis and steatosis, in liver transplant recipients who were over 10 years posttrans-plant. In addition, we aimed to identify factors that influence liver function and quality of life in these patients.

Materials and methods: This prospective, crosssectional study included 105 liver transplant recipients. Vibration-controlled transient elastography measurements (controlled attenuation parameter and liver stiffness measurement) were used to assess liver steatosis and fibrosis, and the Short Form 36 quality of life questionnaire was use to evaluate overall health of patients. Demographic data, medical history, and laboratory results were also collected. Generalized linear models identified significant factors that may affect liver function and quality of life.

Results: No significant differences were observed between liver transplant recipients with living donors versus recipients with deceased donors with regard to fibrosis, quality of life, or other factors. The study found that diabetes mellitus (controlled attenuation parameter: P = 0.278; 95% CI, 0.193-0.363; P < .001) and history of biopsy-proven rejection (liver stiffness measurement: β = 0.814; 95% CI, 0.653-0.975; P < .001) were key factors associated with greater severity of liver steatosis and fibrosis. Significant fibrosis was associated with lower physical function scores (β = -0.207; P = .040).

Conclusions: Vibration-controlled transient elastography is a valuable tool for assessment of liver fibrosis and steatosis in long-term liver transplant recipients and thereby facilitates optimization of posttransplant care and improved outcomes.