Depression and Risk of Sudden Cardiac Death and Arrhythmias: A Systematic Review and Meta-Analysis.

IF 1.3 4区医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS

Reviews in cardiovascular medicine Pub Date : 2025-08-29 eCollection Date: 2025-08-01 DOI:10.31083/RCM36520

Yao You, Yongmin Shi, Qingwen Yu, Xiyun Rao, Xuhan Tong, Ting Tang, Siqi Hu, Shenghui Zhang, Xingwei Zhang, Hu Wang, Mingwei Wang, Jiake Tang

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引用次数: 0

Abstract

Background: Depression is a highly prevalent mental disorder worldwide and is often accompanied by various somatic symptoms. Clinical studies have suggested a close association between depression and cardiac electrophysiological instability, particularly sudden cardiac death (SCD) and arrhythmias. Therefore, this review systematically evaluated the association between depression and the risks of SCD, atrial fibrillation (AF), and ventricular arrhythmias.

Methods: This analysis was conducted in accordance with the Preferred Reporting Items for Systematic reviews and Meta-Analyses guidelines. The PubMed, Embase, Web of Science, China National Knowledge Infrastructure, VIP, and Wanfang databases were comprehensively searched to identify studies that indicated a correlation between depression and the risk of SCD and arrhythmias from database inception until April 10, 2025. Numerous well-qualified cohort studies were incorporated in this analysis. Correlation coefficients were computed using a random effects model. Statistical analyses were performed using Review Manager 5.4 and STATA 16.0.

Results: A total of 20 studies were included in this meta-analysis. We explored the relationship between depression and SCD as well as arrhythmias. Of these diseases, SCD exhibited a statistically significant association with depression (hazard ratio (HR), 2.52, 95% confidence interval (CI): 1.82-3.49). Ventricular tachycardia (VT)/ventricular fibrillation (VF) was also significantly correlated with depression (HR): 1.38, 95% CI: 1.03-1.86). Depression was also considerably more likely to develop following AF. The results also indicated that AF recurrence (HR: 1.89, 95% CI: 1.54-2.33) was more significant than new-onset AF (HR: 1.10, 95% CI: 0.98-1.25).

Conclusions: This study highlights a significant association between depression and elevated risks of SCD and arrhythmias, including both AF and VT/VF. These findings underscore the importance of incorporating mental health evaluation into comprehensive cardiovascular risk management strategies.

The prospero registration: CRD42024498196, https://www.crd.york.ac.uk/PROSPERO/view/CRD42024498196.

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抑郁与心源性猝死和心律失常的风险：系统回顾和荟萃分析。

背景：抑郁症是世界范围内非常普遍的精神障碍，通常伴有各种躯体症状。临床研究表明，抑郁与心脏电生理不稳定，特别是心源性猝死（SCD）和心律失常密切相关。因此，本综述系统地评估了抑郁与SCD、心房颤动（AF）和室性心律失常风险之间的关系。方法：根据系统评价和荟萃分析指南的首选报告项目进行分析。全面检索PubMed、Embase、Web of Science、中国国家知识基础设施、VIP和万方数据库，以确定从数据库建立到2025年4月10日之间表明抑郁与SCD和心律失常风险相关的研究。该分析纳入了许多合格的队列研究。使用随机效应模型计算相关系数。使用Review Manager 5.4和STATA 16.0进行统计分析。结果：本meta分析共纳入20项研究。我们探讨抑郁与SCD及心律失常之间的关系。在这些疾病中，SCD与抑郁症的相关性具有统计学意义（风险比为2.52,95%可信区间为1.82-3.49）。室性心动过速(VT)/室颤（VF）也与抑郁（HR）显著相关（HR: 1.38, 95% CI: 1.03-1.86）。房颤后出现抑郁的可能性也显著增加。结果还表明，房颤复发（HR: 1.89, 95% CI: 1.54-2.33）比新发房颤（HR: 1.10, 95% CI: 0.98-1.25）更为显著。结论：本研究强调了抑郁与SCD和心律失常（包括房颤和室性心动过速/室性心动过速）风险升高之间的显著关联。这些发现强调了将心理健康评估纳入综合心血管风险管理策略的重要性。普洛斯彼罗注册：CRD42024498196， https://www.crd.york.ac.uk/PROSPERO/view/CRD42024498196。

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来源期刊

Reviews in cardiovascular medicine 医学-心血管系统

CiteScore

2.70

自引率

3.70%

发文量

377

审稿时长

1 months

期刊介绍： RCM is an international, peer-reviewed, open access journal. RCM publishes research articles, review papers and short communications on cardiovascular medicine as well as research on cardiovascular disease. We aim to provide a forum for publishing papers which explore the pathogenesis and promote the progression of cardiac and vascular diseases. We also seek to establish an interdisciplinary platform, focusing on translational issues, to facilitate the advancement of research, clinical treatment and diagnostic procedures. Heart surgery, cardiovascular imaging, risk factors and various clinical cardiac & vascular research will be considered.