Toni Habib, Micaela Prisco, Peter Mouanes, Chloe Lahoud, Saif Yasin, Ali Sohail, Hassan Al Moussawi
{"title":"Rapid Metastatic Growth of A Pancreatic Signet Ring Cell Carcinoma within 6 weeks of A Negative CT.","authors":"Toni Habib, Micaela Prisco, Peter Mouanes, Chloe Lahoud, Saif Yasin, Ali Sohail, Hassan Al Moussawi","doi":"10.12890/2025_005662","DOIUrl":null,"url":null,"abstract":"<p><p>Pancreatic signet ring cell carcinoma (PSRCC) is a rare and aggressive subtype of pancreatic cancer with a dismal prognosis. We present the case of a 50-year-old male who, within six weeks, developed a pancreatic mass with liver metastases. Endoscopic ultrasound-guided biopsy confirmed PSRCC. The presentation of this tumour with distant metastasis after a negative computed tomography (CT) of the abdomen and pelvis six weeks prior underscores the highly aggressive nature of PSRCC and the crucial need for heightened clinical suspicion, especially in cases with persistent or atypical abdominal pain. This case highlights the limitations of current diagnostic modalities and emphasises the urgent need for further research into improved early detection methods, molecular characterisation and effective treatment strategies for this rare and lethal subtype of pancreatic cancer.</p><p><strong>Learning points: </strong>Aggressive malignancy can become metastatic within six weeks of a negative CT scan.A CT scan may not detect a small pancreatic lesion <2 cm.</p>","PeriodicalId":11908,"journal":{"name":"European journal of case reports in internal medicine","volume":"12 9","pages":"005662"},"PeriodicalIF":0.0000,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12416782/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"European journal of case reports in internal medicine","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.12890/2025_005662","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q3","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 0
Abstract
Pancreatic signet ring cell carcinoma (PSRCC) is a rare and aggressive subtype of pancreatic cancer with a dismal prognosis. We present the case of a 50-year-old male who, within six weeks, developed a pancreatic mass with liver metastases. Endoscopic ultrasound-guided biopsy confirmed PSRCC. The presentation of this tumour with distant metastasis after a negative computed tomography (CT) of the abdomen and pelvis six weeks prior underscores the highly aggressive nature of PSRCC and the crucial need for heightened clinical suspicion, especially in cases with persistent or atypical abdominal pain. This case highlights the limitations of current diagnostic modalities and emphasises the urgent need for further research into improved early detection methods, molecular characterisation and effective treatment strategies for this rare and lethal subtype of pancreatic cancer.
Learning points: Aggressive malignancy can become metastatic within six weeks of a negative CT scan.A CT scan may not detect a small pancreatic lesion <2 cm.
期刊介绍:
The European Journal of Case Reports in Internal Medicine is an official journal of the European Federation of Internal Medicine (EFIM), representing 35 national societies from 33 European countries. The Journal''s mission is to promote the best medical practice and innovation in the field of acute and general medicine. It also provides a forum for internal medicine doctors where they can share new approaches with the aim of improving diagnostic and clinical skills in this field. EJCRIM welcomes high-quality case reports describing unusual or complex cases that an internist may encounter in everyday practice. The cases should either demonstrate the appropriateness of a diagnostic/therapeutic approach, describe a new procedure or maneuver, or show unusual manifestations of a disease or unexpected reactions. The Journal only accepts and publishes those case reports whose learning points provide new insight and/or contribute to advancing medical knowledge both in terms of diagnostics and therapeutic approaches. Case reports of medical errors, therefore, are also welcome as long as they provide innovative measures on how to prevent them in the current practice (Instructive Errors). The Journal may also consider brief and reasoned reports on issues relevant to the practice of Internal Medicine, as well as Abstracts submitted to the scientific meetings of acknowledged medical societies.