Thyroid Hormones Correlate to the Therapeutic Effect of Ovulation Induction in Infertile Women With Polycystic Ovary Syndrome.

IF 2.4 3区 医学 Q2 ENDOCRINOLOGY & METABOLISM
Xuefei Hao, Shasha Liu, Hanjing Zheng, Qiuchen Wang, Lizhen Jin, Jing Ma
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Abstract

Background: Polycystic ovary syndrome (PCOS) is a prevalent endocrine and metabolic disorder affecting 5%-10% of reproductive-age women, accounting for 50%-70% of anovulatory infertility. Thyroid function, particularly the relationship between subclinical hypothyroidism (SCH) and PCOS, has garnered attention due to its potential impact on metabolic and reproductive health.

Methods: This study included 143 infertile women with PCOS diagnosed based on the Rotterdam criteria. Participants underwent ovulation induction using clomiphene citrate following pretreatment with Diane-35. Serum levels of triiodothyronine (T3), thyroxine (T4), and thyroid-stimulating hormone (TSH) were measured pre- and posttherapy. Outcomes were compared between therapy-responsive (n = 97) and nonresponsive (n = 46) groups. Receiver operating characteristic (ROC) analysis evaluated the predictive value of T3, T4, and TSH levels for treatment outcomes.

Results: Significant differences in baseline T3, T4, and TSH levels were observed between responsive and nonresponsive groups (p < 0.001). Posttreatment, serum T3 and T4 increased while TSH decreased in the responsive group, whereas no significant changes were noted in the nonresponsive group. Combined ROC analysis of T3, T4, and TSH improved predictive accuracy (AUC = 0.88, sensitivity = 76.09%, specificity = 86.60%). Endometrial thickness positively correlated with T3 and T4 and negatively with TSH.

Conclusions: Thyroid hormones significantly influence the efficacy of ovulation induction in infertile women with PCOS. Combined T3, T4, and TSH measurements enhance predictive accuracy for therapeutic responses, providing a foundation for personalized treatment strategies.

甲状腺激素与多囊卵巢综合征不孕妇女促排卵治疗效果的关系。
背景:多囊卵巢综合征(PCOS)是一种常见的内分泌和代谢疾病,影响5%-10%的育龄妇女,占无排卵性不孕的50%-70%。甲状腺功能,特别是亚临床甲状腺功能减退症(SCH)与多囊卵巢综合征(PCOS)之间的关系,由于其对代谢和生殖健康的潜在影响而引起了人们的关注。方法:本研究纳入143例根据鹿特丹标准诊断为PCOS的不孕妇女。参与者在Diane-35预处理后使用克罗米芬柠檬酸诱导排卵。测定治疗前后血清三碘甲状腺原氨酸(T3)、甲状腺素(T4)、促甲状腺激素(TSH)水平。比较治疗反应组(n = 97)和无反应组(n = 46)的结果。受试者工作特征(ROC)分析评估T3、T4和TSH水平对治疗结果的预测价值。结果:反应组和无反应组的基线T3、T4和TSH水平有显著差异(p)。结论:甲状腺激素显著影响PCOS不孕妇女的促排卵效果。T3、T4和TSH联合测量提高了治疗反应预测的准确性,为个性化治疗策略提供了基础。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Clinical Endocrinology
Clinical Endocrinology 医学-内分泌学与代谢
CiteScore
6.40
自引率
3.10%
发文量
192
审稿时长
1 months
期刊介绍: Clinical Endocrinology publishes papers and reviews which focus on the clinical aspects of endocrinology, including the clinical application of molecular endocrinology. It does not publish papers relating directly to diabetes care and clinical management. It features reviews, original papers, commentaries, correspondence and Clinical Questions. Clinical Endocrinology is essential reading not only for those engaged in endocrinological research but also for those involved primarily in clinical practice.
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