Modeling and sensitivity analysis of reaction diffusion brain disease with control rate under neurological disorder

IF 3.2 Q3 Mathematics
Muhammad Farman , Ammara Talib , Aqeel Ahmad , Muhammad Owais Kulachi , Aceng Sambas , Mohamed Hafez
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Abstract

The central nervous system (CNS) is frequently affected by multiple sclerosis, a common neurological condition that can result in lesions that progress over time and space. Our work provides a mathematical model that demonstrate the course of the illness and its probability of return. A fractional order model is obtained by applying the fractal–fractional operator to a mathematical model that is designed with the notion of enhancing immune system development. To identify its stable location, a recently created system HIIvTR is analyzed statistically and qualitatively. The study guarantees trustworthy bounded conclusions by examining the system’s well-posedness and local and global stability, which are critical characteristics of epidemic models. The Lipschitz condition is used with a fixed point theory tool to satisfy uniqueness and existence constraints. Additionally, the reproductive number is ascertained using a sensitivity study of factors including chaos control. Lyapunov first derivative functions are used to analyze the system for local and global stability in order to assess the overall impact of these measurements. By using power-law kernel at fractional orders, a dependable solution is derived by the use of the fractal–fractional operator. Furthermore, we confirm our theoretical results using numerical simulations. Our results are shown in graphs that illustrate the model’s different reactions for different values of the parameters.
神经障碍下控制率的反应弥漫性脑疾病建模及敏感性分析
中枢神经系统(CNS)经常受到多发性硬化症的影响,多发性硬化症是一种常见的神经系统疾病,可导致病变随着时间和空间的推移而发展。我们的工作提供了一个数学模型,展示了疾病的过程及其复发的概率。将分形-分数阶算子应用于以增强免疫系统发育为目的的数学模型,得到了分数阶模型。为了确定其稳定的位置,对新创建的HIIvTR系统进行了统计和定性分析。该研究通过检验系统的适定性以及局部和全局稳定性,保证了可信的有界结论,这是流行病模型的关键特征。利用Lipschitz条件和不动点理论工具来满足唯一性和存在性约束。此外,利用包括混沌控制在内的因素的敏感性研究确定了繁殖数。李雅普诺夫一阶导数函数用于分析系统的局部和全局稳定性,以评估这些测量的总体影响。利用分数阶幂律核,利用分形-分数阶算子,得到了一个可靠的解。此外,我们用数值模拟验证了我们的理论结果。我们的结果用图表显示了模型对不同参数值的不同反应。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Results in Control and Optimization
Results in Control and Optimization Mathematics-Control and Optimization
CiteScore
3.00
自引率
0.00%
发文量
51
审稿时长
91 days
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