[Predictors of mortality in neonatal spontaneous gastric perforation: a multiple-center study].

Q4 Medicine
M Yu Tishukov, I I Tishukova, V M Voropaev, A V Muraviev, T A Garapov, V V Ignat'ev
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引用次数: 0

Abstract

Objective: To analyze clinical data and predictors of mortality in neonatal spontaneous gastric perforation (SGP).

Material and methods: A two-center retrospective cohort study included neonates diagnosed with SGP between 1999 and 2023. This cohort was divided into survivors and dead neonates to identify prognostic factors of mortality.

Results: There were 11 neonates (male-to-female ratio 8:3). Mean gestational age was 33±3.2 weeks. Nine (82%) ones were preterm infants. The mortality rate was 54.5% (6/11), mean age - 7.7 days (range 2-20). The most common signs were abdominal distension and respiratory distress. All patients had pneumoperitoneum upon admission. Concomitant gastrointestinal anomalies were necrotizing enterocolitis (3 patients), gastroschisis (1 patient), and tracheoesophageal fistula (1 patient). Neonatal respiratory distress syndrome (RDS) is a prognostic factor of fatal outcome in patients with SGP. RDS in patients with SGP increases the probability of death by 39 times (OR 39.0; 95% CI 1.3 - 1191; p=0.04).

Conclusion: RDS is a prognostic factor of mortality in neonates with SGP. Identification of modifiable prognostic factors of mortality in critical periods of life of neonates with SPG will facilitate effective strategies for prevention and treatment of this pathology.

[新生儿自发性胃穿孔死亡率预测因素:一项多中心研究]。
目的:分析新生儿自发性胃穿孔(SGP)的临床资料及死亡率预测因素。材料和方法:一项双中心回顾性队列研究纳入了1999年至2023年间诊断为SGP的新生儿。该队列分为幸存者和死亡新生儿,以确定死亡的预后因素。结果:新生儿11例(男女比例8:3)。平均胎龄33±3.2周。9例(82%)为早产儿。死亡率为54.5%(6/11),平均年龄- 7.7天(范围2-20)。最常见的症状是腹胀和呼吸窘迫。所有患者入院时均有气腹。同时发生的胃肠道异常有坏死性小肠结肠炎3例,胃裂1例,气管食管瘘1例。新生儿呼吸窘迫综合征(RDS)是SGP患者致命结局的预后因素。SGP患者的RDS使死亡概率增加39倍(OR 39.0; 95% CI 1.3 - 1191; p=0.04)。结论:RDS是影响SGP新生儿死亡的一个预后因素。在患有SPG的新生儿生命的关键时期,确定可改变的死亡预后因素将有助于有效的预防和治疗这种病理的策略。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Khirurgiya
Khirurgiya Medicine-Medicine (all)
CiteScore
0.70
自引率
0.00%
发文量
161
期刊介绍: Хирургия отдельных областей сердце, сосуды легкие пищевод молочная железа желудок и двенадцатиперстная кишка кишечник желчевыводящие пути печень
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