The therapeutic effects of various tonic traditional Chinese medicines on demyelinating diseases.

IF 3.5 3区医学 Q2 ENDOCRINOLOGY & METABOLISM

Metabolic brain disease Pub Date : 2025-09-09 DOI:10.1007/s11011-025-01702-x

Cunming Lv, Qiang Li, Jinhao Chen

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Abstract

Demyelinating diseases, a prevalent group of neurological disorders, lead to impaired nerve conduction and sensorimotor dysfunctions. Despite existing treatments demonstrating some efficacy, their limitations have driven research toward exploring natural remedies. This review summarizes the therapeutic potential of four traditional tonic Chinese herbal medicines-ginsenosides, deer antler polypeptides, resveratrol, and ginkgo leaf extracts-for demyelinating diseases. The selection of these four components is based on their reported neuroprotective and immunomodulatory effects in recent studies. Ginsenosides can modulate immune functions, counteract oxidative stress, and promote remyelination in demyelinating injuries caused by inflammatory conditions. Deer antler polypeptides facilitate remyelination by regulating the expression of myelin-related proteins. Resveratrol exhibits antioxidant and anti-inflammatory properties, alleviating the symptoms of chronic demyelinating diseases induced by metabolic disturbances. Among the components of ginkgo leaf extracts, flavonoids protect neurons and inhibit apoptosis, while terpene lactones modulate the expression of myelin-related genes. This review summarizes the current research on these tonic Chinese herbal medicines and discusses their potential applications in treating demyelinating diseases. This comprehensive review evaluates the research progress on these essential tonic Chinese herbal medicines, revealing their potential applications in demyelinating disease treatments. It may offer a basis for future investigations and potential implications for clinical research.

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各种补益中药对脱髓鞘性疾病的治疗作用。

脱髓鞘疾病是一种常见的神经系统疾病，可导致神经传导受损和感觉运动功能障碍。尽管现有的治疗方法显示出一定的疗效，但它们的局限性促使研究转向探索自然疗法。本文综述了人参皂苷、鹿茸多肽、白藜芦醇和银杏叶提取物四种传统补益类中药对脱髓鞘疾病的治疗潜力。这四种成分的选择是基于它们在最近的研究中报道的神经保护和免疫调节作用。人参皂苷可以调节免疫功能，对抗氧化应激，促进炎症引起的脱髓鞘损伤的再脱髓鞘。鹿茸多肽通过调节髓磷脂相关蛋白的表达促进髓鞘再生。白藜芦醇具有抗氧化和抗炎特性，可减轻代谢紊乱引起的慢性脱髓鞘疾病的症状。银杏叶提取物中黄酮类化合物具有保护神经元和抑制细胞凋亡的作用，而萜烯内酯可调节髓磷脂相关基因的表达。本文综述了这些补益类中药的研究现状，并对其在脱髓鞘疾病治疗中的潜在应用进行了探讨。本文综述了这些补益类中药的研究进展，揭示了它们在脱髓鞘疾病治疗中的潜在应用。为今后的研究和临床研究提供了基础。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Metabolic brain disease 医学-内分泌学与代谢

CiteScore

5.90

自引率

5.60%

发文量

248

审稿时长

6-12 weeks

期刊介绍： Metabolic Brain Disease serves as a forum for the publication of outstanding basic and clinical papers on all metabolic brain disease, including both human and animal studies. The journal publishes papers on the fundamental pathogenesis of these disorders and on related experimental and clinical techniques and methodologies. Metabolic Brain Disease is directed to physicians, neuroscientists, internists, psychiatrists, neurologists, pathologists, and others involved in the research and treatment of a broad range of metabolic brain disorders.