The association between sleep quality and cognitive function in patients with non-functioning pituitary adenoma.

IF 2.8 3区医学 Q3 ENDOCRINOLOGY & METABOLISM

Endocrine Connections Pub Date : 2025-09-23 Print Date: 2025-09-01 DOI:10.1530/EC-25-0082

M Brown, I L Ross, W Nkoana, M Henry

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引用次数: 0

Abstract

Background: Cortisol and growth hormone are important for sleep regulation and cognition. Sleep is critical for cognitive functioning and memory consolidation. Patients with pituitary disease experience hormonal dysregulation, impaired sleep quality, and cognitive dysfunction. We wished to examine the relationship between objective sleep and cognitive functioning in patients with pituitary adenomas.

Methods: Ten patients with non-functioning pituitary adenomas (NFPA) and ten healthy controls were assessed using a crossover design. Each participant was administered standardised neuropsychological tests (Wechsler logical memory test (LMT) and finger tapping task (FTT)) assessing declarative and procedural memory performance after a period of sleep and after an equivalent period of wakefulness. Objective sleep data were elicited, and the Pittsburgh Sleep Diary captured self-reported sleep data.

Results: Controls performed better than patients with NFPA on retention on the LMT (P = 0.027). Objective measures of sleep quality revealed no between-group differences, whereas controls reported better subjective sleep quality (P = 0.016) and being more alert when awake (P = 0.015) than patients. Generally, sleep was not related to cognition in either group.

Conclusions: Patients demonstrated poorer performance on declarative memory tasks, but not poorer sleep. Interventions for memory rehabilitation may assist their capacity to complete other important daily activities.

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无功能垂体腺瘤患者睡眠质量与认知功能的关系。

背景：皮质醇和生长激素对睡眠调节和认知有重要作用。睡眠对认知功能和记忆巩固至关重要。垂体疾病患者会经历激素失调、睡眠质量受损和认知功能障碍。我们希望研究垂体腺瘤患者客观睡眠与认知功能之间的关系。方法：采用交叉设计对10例无功能垂体腺瘤（NFPA）患者和10例健康对照（HC）进行评估。每个参与者都进行了标准化的神经心理测试（韦氏逻辑记忆测试[LMT]和手指敲击任务[FTT]），评估了一段时间的睡眠和同等时间的清醒后的陈述性和程序性记忆表现。客观的睡眠数据被提取出来，匹兹堡睡眠日记收集了自我报告的睡眠数据。结果：对照组在LMT上的保留效果优于NFPA患者（p = 0.027）。客观的睡眠质量测量结果没有显示组间差异，而对照组的主观睡眠质量（p = 0.016）和清醒时的警觉性（p = 0.015）均优于患者。总的来说，两组的睡眠都与认知无关。结论：患者在陈述性记忆任务上表现较差，但睡眠不差。记忆康复干预可能有助于他们完成其他重要日常活动的能力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Endocrine Connections Medicine-Internal Medicine

CiteScore

5.00

自引率

3.40%

发文量

361

审稿时长

6 weeks

期刊介绍： Endocrine Connections publishes original quality research and reviews in all areas of endocrinology, including papers that deal with non-classical tissues as source or targets of hormones and endocrine papers that have relevance to endocrine-related and intersecting disciplines and the wider biomedical community.