Grace Carvajal Mulatti , Tayrine Mazotti de Moraes , Eduardo Corvello Teixeira , Priscilla Matos Cunha , Taina Gomes Curado de Barros , Ana Beatriz Madeira Boffa , Dilson Pimentel-Junior , Guilherme Baumgardt Barbosa Lima , André Brito-Queiroz , Pedro Puech-Leão , Nelson De Luccia
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引用次数: 0
Abstract
Background
To investigate whether endovascular repair of ruptured abdominal aortic aneurysm (RAAA), performed whenever anatomically feasible, would be superior in a real-world registry.
Methods
Retrospective analysis of consecutive RAAA patients treated at the emergency department of a single hospital from January 2011 to December 2023, after implementation of protocol-based care. The variables of interest were hemodynamic stability, proximal neck length, and type of intervention. The outcomes were 30-day mortality and long-term survival. Statistical analyses were conducted using the chi-square test, Student's t-test, and Pearson correlation. Logistic regression was used to construct a propensity score for matching, and survival rates were illustrated using Kaplan–Meier curves.
Results
Among 209 treated patients, anatomical location included infrarenal, isolated iliac, and juxta-renal aneurysms. Endovascular repair was performed in 121 patients (57.9%), with a significant difference in proximal neck length compared to the open repair group (median 19.7 mm vs. 7.9 mm, P < 0.001). Hemodynamic instability was present in 39% at admission. The overall 30-day mortality rate was 44%; endovascular repair was associated with lower mortality (34.7%, P = 0.001, 95% confidence interval: 0.263–0.431) before matching. Factors such as kidney failure, hemodynamic stability, proximal neck length, and morphology were significantly associated with mortality outcomes. However, propensity score matching (PSM, 42 pairs) revealed no statistical superiority of either technique.
Conclusion
While initial analysis indicated lower 30-day mortality in the endovascular group, PSM revealed no significant difference in either 30-day or long-term mortality between endovascular and open repair when anatomically feasible. Intervention choices should be tailored based on individual anatomical circumstances, the expertise of the medical team, and the resources at hand. Our propensity score analysis was the first to consider anatomical features; nevertheless, endovascular repair demonstrated no clear superiority to open repair.
背景:研究血管内修复破裂的腹主动脉瘤(RAAA),在解剖学上可行的情况下进行,是否在现实世界的登记中更优越。方法:回顾性分析2011年1月至2023年12月在某医院急诊科实施方案护理后的连续RAAA患者。感兴趣的变量是血流动力学稳定性、近端颈部长度和干预类型。结果为30天死亡率和长期生存率。采用卡方检验、学生t检验和Pearson相关进行统计分析。使用逻辑回归构建匹配倾向评分,生存率使用Kaplan-Meier曲线表示。结果:209例患者中,解剖位置包括肾下动脉瘤、孤立性髂动脉瘤和肾旁动脉瘤。121例患者(57.9%)进行了血管内修复,与开放修复组相比,近端颈部长度有显著差异(中位19.7 mm vs. 7.9 mm, p < 0.001)。39%的患者在入院时出现血流动力学不稳定。总的30天死亡率为44%;匹配前,血管内修复与较低的死亡率相关(34.7%,p = 0.001, 95% CI: 0.263 - 0.431)。肾功能衰竭、血流动力学稳定性、近端颈部长度和形态学等因素与死亡率结果显著相关。然而,倾向评分匹配(42对)显示两种技术在统计学上都没有优势。结论:虽然初步分析表明血管内组的30天死亡率较低,但倾向评分匹配显示,在解剖可行的情况下,血管内组和开放式修复组的30天或长期死亡率均无显著差异。干预措施的选择应根据个人的解剖情况、医疗团队的专业知识和手头的资源进行调整。我们的倾向评分分析首先考虑了解剖特征;然而,血管内修复并没有明显优于开放修复。
期刊介绍:
Annals of Vascular Surgery, published eight times a year, invites original manuscripts reporting clinical and experimental work in vascular surgery for peer review. Articles may be submitted for the following sections of the journal:
Clinical Research (reports of clinical series, new drug or medical device trials)
Basic Science Research (new investigations, experimental work)
Case Reports (reports on a limited series of patients)
General Reviews (scholarly review of the existing literature on a relevant topic)
Developments in Endovascular and Endoscopic Surgery
Selected Techniques (technical maneuvers)
Historical Notes (interesting vignettes from the early days of vascular surgery)
Editorials/Correspondence