Removal of psychotropic drugs by hemoadsorption with the HA380 cartridge.

IF 1.8 3区医学 Q3 HEMATOLOGY

Blood Purification Pub Date : 2025-09-08 DOI:10.1159/000547371

Taku Furukawa, Yugeesh R Lankadeva, Ian C Baldwin, Pei Chen Connie Ow, Sally Hood, Chin Bin Eap, Antoine Schneider, Laurent A Decosterd, Rinaldo Bellomo

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引用次数: 0

Abstract

Introduction: Psychotropic drug intoxication may require urgent management. Hemoadsorption (HA) may detoxify blood in such cases, but its effect has not been quantified.

Methods: We studied in-vivo removal of valproate, quetiapine and escitalopram with HA using the Jafron HA 380 cartridge in six sheep. We measured the removal rate (RR) and clearance (CL) of each agent over time.

Results: Mean sorbent-based valproate RR was initially 55.8% (CL 58.2 mL/min), but declined to negligible at 120 min. Mean initial RR for quetiapine was > 90% and remained high (72%) at 4-hours with CL of 87.2 mL/min at 10 minutes and 68.7 mL/min at 240 min. Mean RR of escitalopram exceeded 90 % at 10 minutes and decreased to 66.9 % at 4 hours. The mean CL was 88.0 ml/min at 10 min and 63.2 ml/min at 240 min.

Conclusion: HA with the HA380 cartridge achieves effective removal of valproate, quetiapine and escitalopram. For valproate, adsorptive performance progressively declined over the 4-hour treatment period. In contrast, with quetiapine and escitalopram, the function remained substantial for up to 4 hours. Further research is required to optimize HA strategies for these drugs and facilitate clinical translation of HA-based blood detoxification.

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HA380药筒血液吸附去除精神药物的研究。

精神药物中毒可能需要紧急处理。在这种情况下，血液吸附（HA）可能解毒血液，但其效果尚未量化。方法：采用Jafron HA 380药盒，对6只羊进行体内清除丙戊酸、喹硫平和艾司西酞普兰的研究。随着时间的推移，我们测量了每种药剂的去除率（RR）和清除率（CL）。结果：以吸附剂为基础的丙戊酸盐的平均RR最初为55.8% (CL 58.2 mL/min)，但在120 min时下降到可以忽略不计。喹硫平的平均初始RR为90%，在4小时时仍然很高（72%），10分钟时CL为87.2 mL/min， 240分钟时CL为68.7 mL/min。艾司西酞普兰的平均RR在10分钟时超过90%，在4小时时下降到66.9%。10分钟时平均CL为88.0 ml/min， 240分钟时为63.2 ml/min。结论：HA380药盒可有效去除丙戊酸盐、喹硫平和艾司西酞普兰。对于丙戊酸，在4小时的处理期间，吸附性能逐渐下降。相比之下，使用喹硫平和艾司西酞普兰，功能可保持长达4小时。需要进一步的研究来优化这些药物的HA策略，并促进HA基础血液解毒的临床转化。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Blood Purification 医学-泌尿学与肾脏学

CiteScore

5.80

自引率

3.30%

发文量

审稿时长

6-12 weeks

期刊介绍： Practical information on hemodialysis, hemofiltration, peritoneal dialysis and apheresis is featured in this journal. Recognizing the critical importance of equipment and procedures, particular emphasis has been placed on reports, drawn from a wide range of fields, describing technical advances and improvements in methodology. Papers reflect the search for cost-effective solutions which increase not only patient survival but also patient comfort and disease improvement through prevention or correction of undesirable effects. Advances in vascular access and blood anticoagulation, problems associated with exposure of blood to foreign surfaces and acute-care nephrology, including continuous therapies, also receive attention. Nephrologists, internists, intensivists and hospital staff involved in dialysis, apheresis and immunoadsorption for acute and chronic solid organ failure will find this journal useful and informative. ''Blood Purification'' also serves as a platform for multidisciplinary experiences involving nephrologists, cardiologists and critical care physicians in order to expand the level of interaction between different disciplines and specialities.