Implementation of intelligent All-in-one technology in rectal cancer radiotherapy: A retrospective study on automation efficiency and safety

IF 2.2 4区医学 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Journal of Applied Clinical Medical Physics Pub Date : 2025-09-10 DOI:10.1002/acm2.70236

Haoyang Zhai, Jiazhou Wang, Weigang Hu

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引用次数: 0

Abstract

Purpose

This study aims to assess percentage of automated AIO plans that met clinical treatment standards of radiotherapy plans generated by the fully automated All-in-one (AIO) process.

Methods

The study involved 117 rectal cancer patients who underwent AIO treatment. Fully automated regions of interest (ROI) and treatment plans were developed without manual intervention, comparing them to manually generated plans used in clinical practice. Geometric and dosimetric metrics were collected from both automated and manual plans. The relationship between the geometric and dosimetric metrics of the planning target volume (PTV) was evaluated using Spearman correlation analysis. The interquartile range (IQR) method was applied to determine the percentage of automated plans meeting clinical requirements. Additionally, dosimetric metrics for organs at risk (OAR) were compared between automated and manual plans using paired t-tests. The reasons for dose discrepancies were examined based on target volume.

Results

Spearman correlation analysis showed a moderate correlation between geometric metrics and the conformity index (△CI) in dosimetric metrics. The correlation coefficients were as follows: Hausdorff distance (HD, |ρ| = 0.458, p < 0.01), Mean deviation area (MDA, |ρ| = 0.565, p < 0.01), Dice similarity coefficient (DSC, |ρ| = 0.631, p < 0.01), and Jaccard index (JI, |ρ| = 0.632, p < 0.01). Statistical analysis revealed that the mean doses to the bladder and bilateral femoral heads were significantly lower in automated plans compared to manual ones (p < 0.01). This difference is likely due to variations in ROI delineation between automated and manual methods. The IQR method showed that 81.2% of automated AIO plans met clinical requirements without manual intervention.

Conclusion

In routine clinical practice, approximately 81.2% of automated AIO plans met clinical requirements without requiring manual intervention.

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智能一体化技术在直肠癌放疗中的应用：自动化、效率和安全性的回顾性研究

目的本研究旨在评估全自动All-in-one （AIO）流程生成的放疗计划中符合临床治疗标准的自动化AIO计划的百分比。方法117例直肠癌患者行AIO治疗。完全自动化的感兴趣区域（ROI）和治疗计划在没有人工干预的情况下开发，将它们与临床实践中使用的人工生成计划进行比较。从自动和手动计划中收集几何和剂量计量数据。利用Spearman相关分析评价了规划靶体积（PTV）几何指标与剂量指标之间的关系。采用四分位范围（IQR）方法确定满足临床要求的自动化计划的百分比。此外，使用配对t检验比较自动化和手动计划的危险器官（OAR）剂量计量。根据靶体积分析了剂量差异的原因。结果Spearman相关分析显示几何指标与剂量学指标的符合性指数（△CI）呈正相关。相关系数为：Hausdorff distance (HD, |ρ| = 0.458, p < 0.01), Mean deviation area (MDA, |ρ| = 0.565, p < 0.01), Dice similarity coefficient (DSC, |ρ| = 0.631, p < 0.01), Jaccard index （JI, |ρ| = 0.632, p < 0.01）。统计分析显示，与人工方案相比，自动方案对膀胱和双侧股骨头的平均剂量显著降低（p < 0.01）。这种差异很可能是由于自动化和手动方法之间ROI描述的变化。IQR方法显示81.2%的自动AIO计划在没有人工干预的情况下满足临床要求。结论在常规临床实践中，约81.2%的自动AIO方案满足临床要求，无需人工干预。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Applied Clinical Medical Physics 医学-核医学

CiteScore

3.60

自引率

19.00%

发文量

331

审稿时长

3 months

期刊介绍： Journal of Applied Clinical Medical Physics is an international Open Access publication dedicated to clinical medical physics. JACMP welcomes original contributions dealing with all aspects of medical physics from scientists working in the clinical medical physics around the world. JACMP accepts only online submission. JACMP will publish: -Original Contributions: Peer-reviewed, investigations that represent new and significant contributions to the field. Recommended word count: up to 7500. -Review Articles: Reviews of major areas or sub-areas in the field of clinical medical physics. These articles may be of any length and are peer reviewed. -Technical Notes: These should be no longer than 3000 words, including key references. -Letters to the Editor: Comments on papers published in JACMP or on any other matters of interest to clinical medical physics. These should not be more than 1250 (including the literature) and their publication is only based on the decision of the editor, who occasionally asks experts on the merit of the contents. -Book Reviews: The editorial office solicits Book Reviews. -Announcements of Forthcoming Meetings: The Editor may provide notice of forthcoming meetings, course offerings, and other events relevant to clinical medical physics. -Parallel Opposed Editorial: We welcome topics relevant to clinical practice and medical physics profession. The contents can be controversial debate or opposed aspects of an issue. One author argues for the position and the other against. Each side of the debate contains an opening statement up to 800 words, followed by a rebuttal up to 500 words. Readers interested in participating in this series should contact the moderator with a proposed title and a short description of the topic