Feasibility of HyperSight CBCT for adaptive radiation therapy: A phantom benchmark study of dose calculation accuracy and delivery verification on the Halcyon

IF 2.2 4区医学 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Journal of Applied Clinical Medical Physics Pub Date : 2025-09-09 DOI:10.1002/acm2.70245

Nicholas Nelson, Courtney Oare, Geoff Nelson, Thomas Martin, Jessica Huang, Hui Zhao

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引用次数: 0

Abstract

Purpose

The development of on-board cone-beam computed tomography (CBCT) has led to improved target localization and evaluation of patient anatomical change throughout the course of radiation therapy. HyperSight, a newly developed on-board CBCT platform by Varian, has been shown to improve image quality and HU fidelity relative to conventional CBCT. The purpose of this study is to benchmark the dose calculation accuracy of Varian's HyperSight cone-beam computed tomography (CBCT) on the Halcyon platform relative to fan-beam CT-based dose calculations and to perform end-to-end testing of HyperSight CBCT-only based treatment planning.

Methods

A HU to mass density curve was measured for the HyperSight CBCT system and implemented into the Eclipse treatment planning system. Following this, computational dosimetric analysis was performed between dose distributions calculated on CT simulation (CT_sim) and HyperSight CBCT images on two anthropomorphic phantoms for pelvic and head and neck treatment sites. Additionally, an end-to-end test was carried out for a head and neck intensity modulated radiation therapy (IMRT) plan.

Results

The HU to mass density curves acquired on CT_sim and HyperSight CBCT were similar (< 30 HU) for near-water equivalent materials, but deviated for high-density materials, with a maximum difference of 150 HU. For dose calculations, excellent agreement between dose calculations performed on CT_sim and HyperSight CBCT phantom images was observed, where three-dimensional gamma pass rates between the two dose distributions were observed to be $\geq$ 90% at 1%/1 mm (5% threshold). For the end-to-end test, absolute doses were verified to within 1% of ionization chamber measurements, while Delta4+ and portal dosimetry measurements yielded passing results (gamma pass rate $\geq$ 90%) down to 2%/2 mm criterion.

Conclusion

In this study, the accuracy of dose calculations performed on HyperSight CBCT was found to be within 1% of CT_sim calculations for pelvic and head and neck treatment sites. End-to-end results using the RANDO anthropomorphic phantom indicate that HyperSight CBCT images are suitable for radiation treatment planning.

Abstract Image

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HyperSight CBCT用于适应性放射治疗的可行性：Halcyon上剂量计算准确性和递送验证的幻影基准研究

目的：机载锥形束计算机断层扫描技术（CBCT）的发展提高了放射治疗过程中靶定位和对患者解剖变化的评估。Varian最新开发的车载CBCT平台HyperSight，与传统CBCT相比，可以提高图像质量和HU保真度。本研究的目的是对Halcyon平台上Varian的hyperight锥形束计算机断层扫描（CBCT）的剂量计算精度与基于扇束ct的剂量计算进行基准测试，并对仅基于hyperight CBCT的治疗计划进行端到端测试。方法测量HyperSight CBCT系统的HU -质量密度曲线，并将其应用于Eclipse治疗计划系统。在此之后，计算剂量学分析了CT模拟（CTsim）和HyperSight CBCT图像在骨盆和头颈部治疗部位的两个仿人模型上计算的剂量分布。此外，对头颈部调强放射治疗（IMRT）计划进行了端到端测试。结果CTsim和HyperSight CBCT在近水等效材料上获得的HU -质量密度曲线相似（30 HU），而在高密度材料上获得的HU -质量密度曲线存在偏差，最大差值为150 HU。对于剂量计算，在CTsim和HyperSight CBCT幻象图像上进行的剂量计算之间观察到非常好的一致性，在1%/1 mm（5%阈值）下，观察到两种剂量分布之间的三维伽马通过率≥$ \ $ 90%。对于端到端测试，绝对剂量被验证在电离室测量值的1%以内，而德尔塔4+和门脉剂量测量的合格结果（伽马通过率≥90%）降至2%/ 2mm标准。在本研究中，发现HyperSight CBCT对骨盆和头颈部治疗部位的剂量计算精度在CTsim计算的1%以内。使用RANDO拟人化幻影的端到端结果表明，HyperSight CBCT图像适用于放射治疗计划。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Applied Clinical Medical Physics 医学-核医学

CiteScore

3.60

自引率

19.00%

发文量

331

审稿时长

3 months

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