Quality and Quantity: Dual Benefits of Ablative Radiation in Oligometastatic Pancreatic Cancer

IF 3.2 3区医学 Q3 ONCOLOGY

Seminars in Radiation Oncology Pub Date : 2025-09-09 DOI:10.1016/j.semradonc.2025.07.004

Todd A. Aguilera , Ahmed M. Elamir , Ethan B. Ludmir

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引用次数: 0

Abstract

Oligometastatic pancreatic cancer (OPanc) poses significant opportunities in management, as increasingly metastases can be safely and effectively targeted with local therapy. We review the existing literature on SABR for OPanc, highlighting its potential benefits and limitations with an aim to define the trajectory of opportunity. SABR may offer a meaningful benefit to patients with OPanc, improving quality of life by enabling breaks from systemic therapy while potentially enhancing quantity of life or survival. Patient selection and clearly defined goals will be critical to demonstrate the value of this approach, and well powered prospective studies may be key. The most intriguing aspect of this discussion is the potential for SABR to enhance antitumor immunity that may play a role in prolonged minimal residual disease that can be achieved in some patients. This can translate to improved quality of life by reducing the need for systemic therapy. This approach may offer a novel solution to the treatment challenges associated with OPanc. Further research is needed to confirm the hypotheses and establish the definitive role of SABR in OPanc treatment.

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质与量：消融放疗治疗少转移性胰腺癌的双重益处

少转移性胰腺癌（OPanc）在治疗中提供了重要的机会，因为越来越多的转移可以安全有效地靶向局部治疗。我们回顾了现有的关于OPanc SABR的文献，强调了其潜在的好处和局限性，目的是确定机会的轨迹。SABR可能为OPanc患者提供有意义的益处，通过中断全身治疗来改善生活质量，同时潜在地增加生命或生存期。患者选择和明确定义的目标对于证明这种方法的价值至关重要，而强有力的前瞻性研究可能是关键。这个讨论中最有趣的方面是SABR增强抗肿瘤免疫的潜力，这可能在一些患者中实现的延长的最小残留疾病中发挥作用。这可以通过减少对全身治疗的需求来改善生活质量。这种方法可能为与OPanc相关的治疗挑战提供一种新的解决方案。需要进一步的研究来证实这些假设，并确定SABR在OPanc治疗中的明确作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Seminars in Radiation Oncology 医学-核医学

CiteScore

5.80

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Each issue of Seminars in Radiation Oncology is compiled by a guest editor to address a specific topic in the specialty, presenting definitive information on areas of rapid change and development. A significant number of articles report new scientific information. Topics covered include tumor biology, diagnosis, medical and surgical management of the patient, and new technologies.