Cyclodextrin-based therapeutics delivery systems: A review of current clinical trials

Q2 Agricultural and Biological Sciences

Current Research in Pharmacology and Drug Discovery Pub Date : 2025-01-01 DOI:10.1016/j.crphar.2025.100232

Gjylije Hoti , Neha Bajwa , Fabrizio Caldera , Preet Amol Singh , Ibrahim Hussein , Claudio Cecone , Adrián Matencio , Rita Spagnolo , Monica Argenziano , Roberta Cavalli , Jitender Madan , Francesco Trotta

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Abstract

This review highlights the current status of cyclodextrin-based formulations tested in human participants, highlighting ongoing clinical research in this area. It provides a comprehensive link between the structure, properties, and clinical applications of these formulations, bridging the gap between medical theory and practical use. The aim of this work is to support the future commercialization of cyclodextrin-based therapies for patient care. Additionally, it emphasizes the need for expanded clinical investigations on cyclodextrin-based formulations, particularly cyclodextrin-based polymers, to pave the way for their successful introduction to the market. This is related to the potential of cyclodextrin-based polymers as advanced drug delivery systems, improving the therapeutic efficacy of numerous drugs. Expanding clinical trials will contribute to the optimization of cyclodextrin-based polymer synthesis, boosting their effectiveness as nanocarriers and facilitating the discovery of new disease treatments.

This review also explores the potential of artificial intelligence (AI) to support clinical and medical solutions.

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基于环糊精的治疗递送系统：当前临床试验综述

这篇综述强调了环糊精为基础的配方在人类参与者中测试的现状，强调了这一领域正在进行的临床研究。它提供了这些配方的结构、性质和临床应用之间的全面联系，弥合了医学理论和实际应用之间的差距。这项工作的目的是支持环糊精为基础的治疗病人护理的未来商业化。此外，它强调需要扩大基于环糊精的配方的临床研究，特别是基于环糊精的聚合物，为其成功推向市场铺平道路。这与基于环糊精的聚合物作为先进药物递送系统的潜力有关，可以提高许多药物的治疗效果。扩大临床试验将有助于优化环糊精基聚合物的合成，提高其作为纳米载体的有效性，并促进发现新的疾病治疗方法。本文还探讨了人工智能（AI）在支持临床和医疗解决方案方面的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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